Slow after hyperpolarisation

Slow after hyperpolarisation

Slow After Hyperpolarisation (sAHP) refers to a prolonged period of hyperpolarisation in a neuron or cardiomyocyte following an action potential or other depolarising spike. In neural circuitry, a train of action potentials may be required to induce a sAHP; this is unlike fast AHPs which require no more than a single action potential. sAHPs are due to an extended potassium flux via calcium activated potassium channels (IKCa) [P. Sah, Ca(2+)-activated K+ currents in neurones: types, physiological roles and modulation. Trends Neurosci. 19 (1996) 150-154] [P. Sah, Channels underlying neuronal calcium-activated potassium currents. Prog. Neurobiol. 66 (2002) 345-353] . The resulting hyperpolarisation lasts for several seconds in a sAHP and effectively inhibits neural activity for this period. Fast and Medium AHPs have shorter periods.

ee also

Calcium activated Potassium Channel

References


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