SPHK1

Sphingosine kinase 1, also known as SPHK1, is a human gene.cite web | title = Entrez Gene: SPHK1 sphingosine kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8877| accessdate = ]

Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1. Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor and serum.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tsukahara T, Mizuno H, Igarashi Y |title= [Molecular diversity of sphingosine kinase] |journal=Tanpakushitsu Kakusan Koso |volume=47 |issue= 4 Suppl |pages= 509–13 |year= 2002 |pmid= 11915350 |doi=
*cite journal | author=Sudo K, Chinen K, Nakamura Y |title=2058 expressed sequence tags (ESTs) from a human fetal lung cDNA library. |journal=Genomics |volume=24 |issue= 2 |pages= 276–9 |year= 1995 |pmid= 7698749 |doi= 10.1006/geno.1994.1616
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Kohama T, Olivera A, Edsall L, "et al." |title=Molecular cloning and functional characterization of murine sphingosine kinase. |journal=J. Biol. Chem. |volume=273 |issue= 37 |pages= 23722–8 |year= 1998 |pmid= 9726979 |doi=
*cite journal | author=Liu H, Sugiura M, Nava VE, "et al." |title=Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19513–20 |year= 2000 |pmid= 10751414 |doi= 10.1074/jbc.M002759200
*cite journal | author=Nava VE, Lacana E, Poulton S, "et al." |title=Functional characterization of human sphingosine kinase-1. |journal=FEBS Lett. |volume=473 |issue= 1 |pages= 81–4 |year= 2000 |pmid= 10802064 |doi=
*cite journal | author=Melendez AJ, Carlos-Dias E, Gosink M, "et al." |title=Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution. |journal=Gene |volume=251 |issue= 1 |pages= 19–26 |year= 2000 |pmid= 10863092 |doi=
*cite journal | author=Pitson SM, D'andrea RJ, Vandeleur L, "et al." |title=Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes. |journal=Biochem. J. |volume=350 Pt 2 |issue= |pages= 429–41 |year= 2001 |pmid= 10947957 |doi=
*cite journal | author=Xia P, Wang L, Moretti PA, "et al." |title=Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 7996–8003 |year= 2002 |pmid= 11777919 |doi= 10.1074/jbc.M111423200
*cite journal | author=Melendez AJ, Khaw AK |title=Dichotomy of Ca2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 17255–62 |year= 2002 |pmid= 11856736 |doi= 10.1074/jbc.M110944200
*cite journal | author=Hayashi S, Okada T, Igarashi N, "et al." |title=Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein. |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 33319–24 |year= 2002 |pmid= 12077123 |doi= 10.1074/jbc.M201442200
*cite journal | author=Lacaná E, Maceyka M, Milstien S, Spiegel S |title=Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity. |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 32947–53 |year= 2002 |pmid= 12080051 |doi= 10.1074/jbc.M202841200
*cite journal | author=Johnson KR, Becker KP, Facchinetti MM, "et al." |title=PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35257–62 |year= 2002 |pmid= 12124383 |doi= 10.1074/jbc.M203033200
*cite journal | author=Pitson SM, Moretti PA, Zebol JR, "et al." |title=The nucleotide-binding site of human sphingosine kinase 1. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49545–53 |year= 2003 |pmid= 12393916 |doi= 10.1074/jbc.M206687200
*cite journal | author=Nava VE, Hobson JP, Murthy S, "et al." |title=Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. |journal=Exp. Cell Res. |volume=281 |issue= 1 |pages= 115–27 |year= 2002 |pmid= 12441135 |doi=
*cite journal | author=MacKinnon AC, Buckley A, Chilvers ER, "et al." |title=Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents. |journal=J. Immunol. |volume=169 |issue= 11 |pages= 6394–400 |year= 2002 |pmid= 12444147 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

External links

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