Central Institute for Experimental Animals

Infobox Organization
name= Central Institute for Experimental Animals
headquarters=Kawasaki, Kanagawa, Japan
leader_title=Director
leader_name=Tatsuji Nomura
formation= 1952
website= http://www.ciea.or.jp/English/eindex.htm

Central Institute for Experimental Animals (CIEA) (実験動物中央研究所) is a research center for experimental animals in Japan. It was founded by Tatsuji Nomura in 1952 with the mission of improving the level of biomedical research.

Main achievements and ongoing projects

*Establishment of the world first and only monitoring center for experimental animals in 1970. Appointed as an International Council for Laboratory Animal Science (ICLAS) Monitoring Center in 1979.
*Development and establishement of Tg-PVR mouse, in which a human poliovirus receptor gene is introduced, used as a safety testing for oral polio vaccine.
*Establishment of Tg-rasH2 mouse, in which a human proto type c-Ha-ras oncogene is introduced, and evaluation of their practical usefulness. Achieved a high level of accuracy in carcinogenicity testing for drugs and reduced the testing period to six months from conventional two years system.cite journal | author = James MacDonald and et.al. | title =The Utility of Genetically Modified Mouse Assays for Identifying Human Carcinogens: A Basic Understanding and Path Forward | journal = Toxicological Sciences | year = 2004 | volume = 77 | pages = 188–194 | doi =10.1093/toxsci/kfh037]
*Establishment of a severe immunodeficient mouse, NOD/Shi-scid, IL-2Rγnull mouse (NOD/SCID/IL-2Rγnull mouse, NOG mouse) and development of its applications to various animal experiments and testing systems.

History

*1952 Founded in Nishitama, Tokyo, Japan
*1957 Authorized as a non-profit research organization under Ministry of Education, Japan
*1962 Specific Pathogen Free (SPF) animal production facility was established in Nogawa, Kawasaki, Japan
*1965 Animal production and supply department was spun off as CLEA Japan, Inc.
*1966 Preclinical Research Laboratory was established
*1969 Germ-free animal facility was established
*1973 Bioscience Research Department was established
*1976 Organized "The 2nd International Workshop on Nude Mice", Tokyo, Chairman T. Nomura
*1979 Appointed as ICLAS Monitoring Center
*1982 Embryological Engineering Laboratory was established
*1985 Laboratory animal monitoring facilities completed
*1987 Developmental Engineering Experiment Manual published
*1988 High priority "Laboratory animal monitoring project" started
*1991 From Six Mice (History of Central Institute for Experimental Animals) published
*1992 Laboratory Animal Cryopreservation Facilities completed
*2001 Center for the Advancement of Health and Biosciences (CAHB) established as a nonprofit organization in the United States
*2002 Global business development was initiated
*2005 NOG mouse patent granted
*2006 Tatsuji Nomura becomes Chairman of the Board of Directors of CIEA
*2006 Organized "The 1st International Workshop on Humanized Mice", Tokyo, Chairman T. Nomura

External links

* [http://www.ciea.or.jp/English/eindex.htm CIEA website]
* [http://www.ciea.or.jp/English/A4_monitoring.htm Monitoring Center]
* [http://www.ciea.or.jp/English/A1_R&D_TgPVR.htm Tg-PVR mice]
* [http://www.ciea.or.jp/English/A1_R&D_rasH2.htm Tg-rasH2 mice]
* [http://www.ciea.or.jp/English/NOGmouse/NOGmouse1.htm NOG mice]

References