Corydalis ambigua

Corydalis ambigua
Scientific classification
Kingdom:	Plantae
Division:	Magnoliophyta
Class:	Magnoliopsida
Order:	Ranunculales
Family:	Papaveraceae
Genus:	Corydalis
Species:	C. ambigua
Binomial name
Corydalis ambigua Cham. & Schltdl.[1]

Corydalis ambigua is a tuberous early flowering east Asian flowering plant species. Its exact native range is obscure due to taxonomic confusion.^[1] It is one of the sources of the drug tetrahydropalmatine.

Medicinal uses

A related species, C. yanhusuo is one of the 50 fundamental herbs used in traditional Chinese medicine. (C. remota is also substituted.^{[citation needed]}) In Chinese it is called yán hú suǒ (Chinese: 延胡索).^{[clarification needed]}

The root of the plant is traditionally used as an analgesic and sedative, used for headache, period pain, spasm pain, gut, smooth muscle and gall bladder pain.^{[citation needed]} It^[specify] is a dopamine receptor antagonist.^{[citation needed]} Analgesic effects last about 2 hours and it does not create tolerance.^{[citation needed]} The alkaloid tetrahydropalmatine also has a number of cardiovascular actions.^{[citation needed]} Derivatives of tetrahydroprotoberberines were found to be useful to increase pain tolerance and for treating drug addiction.^[2] Further they may represent a category of neurotransmitter stabilizer which has potential use in broad range of psychotic and neurological disorders.^[2]

Chemistry

Corydalis ambigua contains a variety of alkaloids including corynoline, acetylcorynoline d-corydalin, dl-tetrahydropalmatine, protopine, tetrahydrocoptisine, dl-tetrahydrocoptisine, d-corybulbine and allo-crytopine.^[3][4][5][6]

See also

• Chinese herbology

References

1. ^ ^{a b} "Corydalis ambigua information from NPGS/GRIN". USDA. 28-Nov-2001. http://www.ars-grin.gov/cgi-bin/npgs/html/taxon.pl?403065. Retrieved 2008-02-04. 
2. ^ ^{a b} Zhen X.-C. 2010 . "Tetrahydroprotoberberines (THPBs) in neuropsychological disorders: Recent development and prospective (Abstract S-33.004)" International Journal of Neuropsychopharmacology 13(SUPPL. 1): 41–41
3. ^ Zhu, Da-Yuan et al. (1981). "IDENTIFICATION OF THE STRUCTURES OF CORYDALIS F, I, J AND K". Acta Chimica Sinica. http://en.cnki.com.cn/Article_en/CJFDTOTAL-HXXB198103013.htm. 
4. ^ Ma, W.g.; Fukushi, Y.; Tahara, S. (1999). "Fungitoxic alkaloids from Hokkaido Corydalis species". Fitoterapia 70 (3): 258–265. doi:10.1016/S0367-326X(99)00045-3. http://www.sciencedirect.com/science/article/pii/S0367326X99000453. 
5. ^ Hiraoka, Noboru et al. (2004). "Alkaloid production by somatic embryo cultures of Corydalis ambigua". Plant Biotechnology 21 (5): 361–366. doi:10.5511/plantbiotechnology.21.361. http://docs.google.com/viewer?a=v&q=cache:-ek1ckxlMJIJ:www.wdc-jp.biz/pdf_store/jspcmb/pdf/pb21_5/21_361.pdf+Corydalis+ambigua+garden+plant&hl=en&pid=bl&srcid=ADGEESi1WgJhdhxL7S9cmE7yDF_PZgmwZSUb_uy8CZD86BwGU1vI9z7LzEzf-mCgQTYhcVYbN0KTMRsF5XZYD6NTv4FyWq8rV-B9TjYUMinNj_X8Ji0XqYZkL4f4TGsqOb-aWTMfw3Il&sig=AHIEtbSyGXyQIL8TlEo5XXC_s1i3ve0UUQ. 
6. ^ Zhu, Xing-Zu (1991). "Memórias do Instituto Oswaldo Cruz - Development of natural products as drugs acting on central nervous system". Memórias do Instituto Oswaldo Cruz 86: 173. doi:10.1590/S0074-02761991000600039. 

Further reading

• Bhakuni, D. S.; Chaturvedi, Rekha (1983). "The Alkaloids of Corydalis meifolia". Journal of Natural Products 46 (4): 466–70. doi:10.1021/np50028a006. PMID 6631434.