Herman Cheung

Herman Cheung is the James L. Knight Professor of Biomedical Engineering at the University of Miami in Coral Gables, Florida. He specializes in Medicine (Geriatrics and Rheumatology) and Orthopedics and Rehabilitation. His areas of research interest are Regenerative Medicine/Tissue Engineering and the Effect of Biomineralization and Aging in Osteoarthritis. Professor Cheung joined the University of Miami faculty in 1996.

In 1968, Professor Cheung received his B.S. in Biological Sciences from Loyola Marymount University in Los Angeles, CA and received his Ph.D. in Molecular Biology from the University of Southern California in 1974.

After finishing school, Dr. Cheung spent the next three years as a Postdoctoral Fellow in Biochemistry at USC. From 1977 to 1996, he worked as a Professor of Biochemistry and Orthopaedic Surgery at the Medical College of Wisconsin in Milwaukee, WI.

Education

B.S. Biological Sciences (1968), Loyola Marymount University, Los Angeles, CA

Ph.D. Molecular Biology (1974), University of Southern California, Los Angeles, CA

elected Publications

Major ML, Cheung HS, Misra RP. Basic calcium phosphate crystals activate c-fos expression through a ras-dependent signaling mechanism. Biochem. Biophys. Res. Comm. 335; 654-660.2007.Huang CY, Cheung HS, Dietzer MA, Effects of fibrinolytic inhibitors on chondrogenesis of bone-marrow derived mesenchymal stem cells in fibrin gels. Biomech Model Mechanobiol. 6:5-11, 2007.

Cheung HS. Crystal/Cell Interactions in Osteoarthritis. Curr Opin in Orthopededics. 17 (5) 424-428, 2006.

Cheung HS, Sallis JD, Demadis KD, Wierzicki A. Phosphocitrate blocks calcification-induced articular joint degeneration. Arthritis & Rheum. 54 (8)2452-2461, 2006. PMID: 1689019.

Wu JY, Lu H, Graham DY, Sun Y, Cheung HS, Yamaoka Y. Balance between Polyoma Enhancing Activator-3 and Activator Protein-1 Regulates Helicobacter pylori-stimulated Matrix Metalloproteinase-1 Expression, Cancer Res. 66 (10): 5111-20, 2006. PMID:16707434

Sallis JD, Demadis KD, Cheung HS. Phosphocitrate, A Potential Therapeutic Agent for Calcium Crystal Deposition Diseases, Curr. Rheum. Reviews. 2(1) 95-99, 2006.

Waveren CV, Sun Y, Cheung HS, Moraes CT. Oxidative phosphorylation dysfunction modulates transcription of extracellular matrix-remodeling genes. Carcinogenesis. 27(3): 409-418, 2006.

Reuben PM, Cheung HS. Regulation of matrix metalloproteinase (MMP) gene expression by protein kinases. Frontiers in Biosciences.1:11:1199-215, 2006.

Cheung HS, Sallis JD, Demadis KD, Wierzicki A. Phosphocitrate blocks calcification-induced articular joint degeneration. Arthritis & Rheum. 54 (8): 2452-2461, 2006

Sallis JD, Demadis KD, Cheung HS. Phosphocitrate, A Potential Therapeutic Agent for Calcium Crystal Deposition Diseases, Curr. Rheum. Reviews. 2(1): 95-99, 2006.

Dalal P, Zannotti K, Wiezbicki A, Madura JD, Cheung HS. Molecular dynamics simulation studies of the effect of phosphocitrate on crystal-induced membranolysis, Biophysical J. 89:1-7, 2005.

Huang CY, Cheung HS. Temporal Expression Patterns of Early Responsive Genes in Rabbit Bone-Marrow Derived Mesenchymal Stem Cells Under Cyclic Compressive Loading. Stem Cells. 23(8):1113-21, 2005

Cheung HS. Biologic effects of calcium-containing crystals. Curr. Opinion Rheum. 17:336-340, 2005

Experience

1974-1977: NIH Postdoctoral Fellow (Biochemistry), U. of Southern California, Los Angeles, CA.

1977-1981: Assistant Professor of Medicine, Biochemistry, and Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, WI.

1981-1986: Associate Professor of Medicine, Biochemistry, and Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, WI.

1986-1996: Professor of Medicine, Biochemistry, and Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, WI.

1996-Present: Professor of Medicine and Professor of Orthopaedic Surgery, U. of Miami, Coral Gables, FL.

1996-2000: Research Biologist, VA Center, Miami, FL.

1999-2004: Research Career Biologist, VA Center, Miami, FL.

1990-2002: NSF Industry/University Center for Biosurfaces, Site Director, U. of Miami, Coral Gables, FL.

2001-Present: Co-Chairman, Cellular & Tissue Engineering Initiative Conference, U of Miami School of Medicine

2001-Present: James L. Knight Professor, Dept. of Biomedical Engineering, U. of Miami

2003-Present: Professor of Biomedical Engineering (Tenure)

2004-Present: Senior Research Career Biologist, VA Center, Miami, FL

2005-Present: Founding member and board member of Walter H Coulter Center for Translational Research, U. of Miami

2007-Present: Member of U. of Miami Interdisciplinary Stem Cell Unit

ources

Dr. Cheung's University of Miami Homepage: [http://www6.miami.edu/UMH/CDA/UMH_Main/1,1770,6425-1;8409-3,00.html]