IQSEC1

IQ motif and Sec7 domain 1 (IQSEC1) is a human gene.cite web | title = Entrez Gene: IQSEC1 IQ motif and Sec7 domain 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9922| accessdate = ] The protein encoded by this gene is also known as ARF-GEP₁₀₀ (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa).cite journal | author = Someya A, Sata M, Takeda K, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M | title = ARF-GEP(100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 5 | pages = 2413–8 | year = 2001 | pmid = 11226253 | doi = 10.1073/pnas.051634798 | issn = ]

Function

The ARF-GEP₁₀₀ protein is involved in signal transduction. It is a guanine nucleotide exchange factor that promotes binding of GTP to ADP ribosylation factor protein ARF6 and to a lesser extent ARF1 and ARF5. This activates the ADP-ribosylation activity of the target protein and cause it to modify its substrates. ARF-GEP₁₀₀, through activation of ARF6, is therefore involved in the control of processes such as endocytosis of plasma membrane proteins, E-cadherin recycling and actin cytoskeleton remodeling.cite journal | author = Hiroi T, Someya A, Thompson W, Moss J, Vaughan M | title = GEP100/BRAG2: activator of ADP-ribosylation factor 6 for regulation of cell adhesion and actin cytoskeleton via E-cadherin and alpha-catenin | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 28 | pages = 10672–7 | year = 2006 | pmid = 16807291 | doi = 10.1073/pnas.0604091103 | issn = ] ARF-GEP₁₀₀ appears particularly important in regulating cell adhesion, with reductions in the level of this protein causing enhanced spreading and attachment of cells.cite journal | author = Dunphy JL, Moravec R, Ly K, Lasell TK, Melancon P, Casanova JE | title = The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins | journal = Curr. Biol. | volume = 16 | issue = 3 | pages = 315–20 | year = 2006 | pmid = 16461286 | doi = 10.1016/j.cub.2005.12.032 | issn = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277–86 |year= 1999 |pmid= 9872452 |doi=
*cite journal | author=Someya A, Sata M, Takeda K, "et al." |title=ARF-GEP(100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 5 |pages= 2413–8 |year= 2001 |pmid= 11226253 |doi= 10.1073/pnas.051634798
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

External links

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