RAPGEF5

Rap guanine nucleotide exchange factor (GEF) 5, also known as RAPGEF5, is a human gene.cite web | title = Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9771| accessdate = ]

PBB_Summary
section_title =
summary_text = Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000). [supplied by OMIM] cite web | title = Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9771| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase T, Seki N, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321–9, 341–54 |year= 1997 |pmid= 9039502 |doi=
*cite journal | author=Ichiba T, Hoshi Y, Eto Y, "et al." |title=Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1. |journal=FEBS Lett. |volume=457 |issue= 1 |pages= 85–9 |year= 1999 |pmid= 10486569 |doi=
*cite journal | author=de Rooij J, Rehmann H, van Triest M, "et al." |title=Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20829–36 |year= 2000 |pmid= 10777494 |doi= 10.1074/jbc.M001113200
*cite journal | author=Rebhun JF, Castro AF, Quilliam LA |title=Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 34901–8 |year= 2001 |pmid= 10934204 |doi= 10.1074/jbc.M005327200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Dupuy AG, L'Hoste S, Cherfils J, "et al." |title=Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac. |journal=Oncogene |volume=24 |issue= 28 |pages= 4509–20 |year= 2005 |pmid= 15856025 |doi= 10.1038/sj.onc.1208647

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