HS2ST1

Heparan sulfate 2-O-sulfotransferase 1, also known as HS2ST1, is a human gene.cite web | title = Entrez Gene: HS2ST1 heparan sulfate 2-O-sulfotransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9653| accessdate = ]

PBB_Summary
section_title =
summary_text = Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes heparan sulfate 2-O-sulfotransferase, a member of the heparan sulfate biosynthetic enzyme family. This family member transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation.cite web | title = Entrez Gene: HS2ST1 heparan sulfate 2-O-sulfotransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9653| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Muramatsu T |title=Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting. |journal=J. Biochem. |volume=127 |issue= 2 |pages= 171–6 |year= 2000 |pmid= 10731680 |doi=
*cite journal | author=Seki N, Ohira M, Nagase T, "et al." |title=Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. |journal=DNA Res. |volume=4 |issue= 5 |pages= 345–9 |year= 1998 |pmid= 9455484 |doi=
*cite journal | author=Rong J, Habuchi H, Kimata K, "et al." |title=Expression of heparan sulphate L-iduronyl 2-O-sulphotransferase in human kidney 293 cells results in increased D-glucuronyl 2-O-sulphation. |journal=Biochem. J. |volume=346 Pt 2 |issue= |pages= 463–8 |year= 2000 |pmid= 10677367 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Aquino RS, Landeira-Fernandez AM, Valente AP, "et al." |title=Occurrence of sulfated galactans in marine angiosperms: evolutionary implications. |journal=Glycobiology |volume=15 |issue= 1 |pages= 11–20 |year= 2005 |pmid= 15317737 |doi= 10.1093/glycob/cwh138
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Xu D, Song D, Pedersen LC, Liu J |title=Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase. |journal=J. Biol. Chem. |volume=282 |issue= 11 |pages= 8356–67 |year= 2007 |pmid= 17227754 |doi= 10.1074/jbc.M608062200

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