LYK5

Protein kinase LYK5, also known as LYK5 or STRAD, is a human protein and also denotes the gene encoding it.cite web | title = Entrez Gene: LYK5 protein kinase LYK5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=92335| accessdate = ] cite journal | author = Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC | title = Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD | journal = EMBO J. | volume = 22 | issue = 12 | pages = 3062–72 | year = 2003 | month = June | pmid = 12805220 | pmc = 162144 | doi = 10.1093/emboj/cdg292 | url = | issn = ]

Function

Endogenous LKB1 and LYK5 form a complex in which LYK5 activates LKB1, resulting in phosphorylation of both partners. Removal of endogenous LYK5 by small interfering RNA abrogates LKB1-induced G1 phase arrest.

Disease linkage

Mutations in the LYK5 gene are associated with polyhydramnios, megalencephaly and symptomatic epilepsy (collectively known as the PMSE syndrome).cite journal | author = Puffenberger EG, Strauss KA, Ramsey KE, Craig DW, Stephan DA, Robinson DL, Hendrickson CL, Gottlieb S, Ramsay DA, Siu VM, Heuer GG, Crino PB, Morton DH | title = Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5 | journal = Brain | volume = 130 | issue = Pt 7 | pages = 1929–41 | year = 2007 | month = July | pmid = 17522105 | doi = 10.1093/brain/awm100 | url = | issn = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Baas AF, Smit L, Clevers H |title=LKB1 tumor suppressor protein: PARtaker in cell polarity. |journal=Trends Cell Biol. |volume=14 |issue= 6 |pages= 312–9 |year= 2004 |pmid= 15183188 |doi= 10.1016/j.tcb.2004.04.001
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scanlan MJ, Gout I, Gordon CM, "et al." |title=Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. |journal=Cancer Immun. |volume=1 |issue= |pages= 4 |year= 2003 |pmid= 12747765 |doi=
*cite journal | author=Baas AF, Boudeau J, Sapkota GP, "et al." |title=Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. |journal=EMBO J. |volume=22 |issue= 12 |pages= 3062–72 |year= 2003 |pmid= 12805220 |doi= 10.1093/emboj/cdg292
*cite journal | author=Boudeau J, Baas AF, Deak M, "et al." |title=MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. |journal=EMBO J. |volume=22 |issue= 19 |pages= 5102–14 |year= 2003 |pmid= 14517248 |doi= 10.1093/emboj/cdg490
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Milburn CC, Boudeau J, Deak M, "et al." |title=Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor. |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 2 |pages= 193–200 |year= 2004 |pmid= 14730349 |doi= 10.1038/nsmb716
*cite journal | author=Lizcano JM, Göransson O, Toth R, "et al." |title=LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. |journal=EMBO J. |volume=23 |issue= 4 |pages= 833–43 |year= 2005 |pmid= 14976552 |doi= 10.1038/sj.emboj.7600110
*cite journal | author=Boudeau J, Scott JW, Resta N, "et al." |title=Analysis of the LKB1-STRAD-MO25 complex. |journal=J. Cell. Sci. |volume=117 |issue= Pt 26 |pages= 6365–75 |year= 2005 |pmid= 15561763 |doi= 10.1242/jcs.01571

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