BCL2L12

Bcl2-like 12 (proline rich), also known as Bcl2L12, is a human gene.cite web | title = Entrez Gene: Bcl2L12 Bcl2-like 12 (proline rich)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83596| accessdate = ] cite journal | author = Scorilas A, Kyriakopoulou L, Yousef GM, Ashworth LK, Kwamie A, Diamandis EP | title = Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family | journal = Genomics | volume = 72 | issue = 2 | pages = 217–21 | year = 2001 | month = March | pmid = 11401436 | doi = 10.1006/geno.2000.6455 | url = | issn = ]

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Bcl2L12 expression is upregulated in most human glioblastomas. Expression of Bcl2L12 results in resistance to apoptosis. Bcl2L12 directly neutralizes caspase-7 (CASP7) and indirectly neutralizes caspase-3 (CASP3) by an indirect mechanism.cite journal | author = Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L | title = Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma | journal = Genes Dev. | volume = 21 | issue = 1 | pages = 98–111 | year = 2007 | month = January | pmid = 17210792 | pmc = 1759904 | doi = 10.1101/gad.1480007 | url = | issn = ] Both caspase enzymes are known to play essential roles in the execution phase of apoptosis.cite journal | author = Wilson MR | title = Apoptosis: unmasking the executioner | journal = Cell Death Differ. | volume = 5 | issue = 8 | pages = 646–52 | year = 1998 | month = August | pmid = 10200519 | doi = 10.1038/sj.cdd.4400394 | url = | issn = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hammond PW, Alpin J, Rise CE, "et al." |title=In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 20898–906 |year= 2001 |pmid= 11283018 |doi= 10.1074/jbc.M011641200
*cite journal | author=Scorilas A, Kyriakopoulou L, Yousef GM, "et al." |title=Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family. |journal=Genomics |volume=72 |issue= 2 |pages= 217–21 |year= 2001 |pmid= 11401436 |doi= 10.1006/geno.2000.6455
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Talieri M, Diamandis EP, Katsaros N, "et al." |title=Expression of BCL2L12, a new member of apoptosis-related genes, in breast tumors. |journal=Thromb. Haemost. |volume=89 |issue= 6 |pages= 1081–8 |year= 2004 |pmid= 12783122 |doi= 10.1267/THRO03061081
*cite journal | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Mathioudaki K, Scorilas A, Papadokostopoulou A, "et al." |title=Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer. |journal=Biol. Chem. |volume=385 |issue= 9 |pages= 779–83 |year= 2005 |pmid= 15493871 |doi=
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

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