- SPG21
Spastic paraplegia 21, maspardin (autosomal recessive, Mast syndrome), also known as SPG21, is a human
gene .PBB_Summary
section_title =
summary_text = The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4.cite web | title = Entrez Gene: SPG21 spastic paraplegia 21, maspardin (autosomal recessive, Mast syndrome)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51324| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Cross HE, McKusick VA |title=The mast syndrome. A recessively inherited form of presenile dementia with motor disturbances. |journal=Arch. Neurol. |volume=16 |issue= 1 |pages= 1–13 |year= 1967 |pmid= 6024251 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3
*cite journal | author=Zeitlmann L, Sirim P, Kremmer E, Kolanus W |title=Cloning of ACP33 as a novel intracellular ligand of CD4. |journal=J. Biol. Chem. |volume=276 |issue= 12 |pages= 9123–32 |year= 2001 |pmid= 11113139 |doi= 10.1074/jbc.M009270200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Simpson MA, Cross H, Proukakis C, "et al." |title=Maspardin is mutated in mast syndrome, a complicated form of hereditary spastic paraplegia associated with dementia. |journal=Am. J. Hum. Genet. |volume=73 |issue= 5 |pages= 1147–56 |year= 2004 |pmid= 14564668 |doi=10.1086/379522
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209PBB_Controls
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