GRAP

GRB2-related adaptor protein, also known as GRAP, is a human gene.cite web | title = Entrez Gene: GRAP GRB2-related adaptor protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10750| accessdate = ]

This gene encodes a member of the GRB2/Sem5 ("C. elegans" homolog)/Drk ("Drosophila" homolog) family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.cite web | title = Entrez Gene: GRAP GRB2-related adaptor protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10750| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Feng GS, Ouyang YB, Hu DP, "et al." |title=Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway. |journal=J. Biol. Chem. |volume=271 |issue= 21 |pages= 12129–32 |year= 1996 |pmid= 8647802 |doi=
*cite journal | author=Trüb T, Frantz JD, Miyazaki M, "et al." |title=The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 894–902 |year= 1997 |pmid= 8995379 |doi=
*cite journal | author=Welsh M, Songyang Z, Frantz JD, "et al." |title=Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. |journal=Oncogene |volume=16 |issue= 7 |pages= 891–901 |year= 1998 |pmid= 9484780 |doi= 10.1038/sj.onc.1201607
*cite journal | author=Zhang W, Sloan-Lancaster J, Kitchen J, "et al." |title=LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. |journal=Cell |volume=92 |issue= 1 |pages= 83–92 |year= 1998 |pmid= 9489702 |doi=
*cite journal | author=Wenzel J, Sanzenbacher R, Ghadimi M, "et al." |title=Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor. |journal=FEBS Lett. |volume=509 |issue= 2 |pages= 255–62 |year= 2002 |pmid= 11741599 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhao C, Ma H, Bossy-Wetzel E, "et al." |title=GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34641–53 |year= 2003 |pmid= 12819203 |doi= 10.1074/jbc.M304594200
*cite journal | author=Shiraiwa H, Takei M, Yoshikawa T, "et al." |title=Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome. |journal=J. Int. Med. Res. |volume=32 |issue= 3 |pages= 284–91 |year= 2004 |pmid= 15174222 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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