USP14

Ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase), also known as USP14, is a human gene.cite web | title = Entrez Gene: USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9097| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.cite web | title = Entrez Gene: USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9097| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=D'Andrea A, Pellman D |title=Deubiquitinating enzymes: a new class of biological regulators. |journal=Crit. Rev. Biochem. Mol. Biol. |volume=33 |issue= 5 |pages= 337–52 |year= 1999 |pmid= 9827704 |doi=
*cite journal | author=Puente XS, Sánchez LM, Overall CM, López-Otín C |title=Human and mouse proteases: a comparative genomic approach. |journal=Nat. Rev. Genet. |volume=4 |issue= 7 |pages= 544–58 |year= 2003 |pmid= 12838346 |doi= 10.1038/nrg1111
*cite journal | author=Deshpande KL, Seubert PH, Tillman DM, "et al." |title=Cloning and characterization of cDNA encoding the rabbit tRNA-guanine transglycosylase 60-kilodalton subunit. |journal=Arch. Biochem. Biophys. |volume=326 |issue= 1 |pages= 1–7 |year= 1996 |pmid= 8579355 |doi= 10.1006/abbi.1996.0039
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Reuter TY, Medhurst AL, Waisfisz Q, "et al." |title=Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. |journal=Exp. Cell Res. |volume=289 |issue= 2 |pages= 211–21 |year= 2003 |pmid= 14499622 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Dennehey BK, Gutches DG, McConkey EH, Krauter KS |title=Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution. |journal=Genomics |volume=83 |issue= 3 |pages= 493–501 |year= 2004 |pmid= 14962675 |doi= 10.1016/j.ygeno.2003.08.017
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hu M, Li P, Song L, "et al." |title=Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. |journal=EMBO J. |volume=24 |issue= 21 |pages= 3747–56 |year= 2005 |pmid= 16211010 |doi= 10.1038/sj.emboj.7600832
*cite journal | author=Shinji S, Naito Z, Ishiwata S, "et al." |title=Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases. |journal=Oncol. Rep. |volume=15 |issue= 3 |pages= 539–43 |year= 2006 |pmid= 16465409 |doi=
*cite journal | author=Crimmins S, Jin Y, Wheeler C, "et al." |title=Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14. |journal=J. Neurosci. |volume=26 |issue= 44 |pages= 11423–31 |year= 2006 |pmid= 17079671 |doi= 10.1523/JNEUROSCI.3600-06.2006

PBB_Controls
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require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes