APBA2BP

Amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein, also known as APBA2BP, is a human gene.cite web | title = Entrez Gene: APBA2BP amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=63941| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.cite web | title = Entrez Gene: APBA2BP amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=63941| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Büssow K, Cahill D, Nietfeld W, "et al." |title=A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. |journal=Nucleic Acids Res. |volume=26 |issue= 21 |pages= 5007–8 |year= 1998 |pmid= 9776767 |doi=
*cite journal | author=Sugita S, Südhof TC |title=Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins. |journal=Biochemistry |volume=39 |issue= 11 |pages= 2940–9 |year= 2000 |pmid= 10715114 |doi=
*cite journal | author=Lee DS, Tomita S, Kirino Y, Suzuki T |title=Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23134–8 |year= 2000 |pmid= 10833507 |doi= 10.1074/jbc.C000302200
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Sugita S, Ho A, Südhof TC |title=NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. |journal=Neuroscience |volume=112 |issue= 1 |pages= 51–63 |year= 2002 |pmid= 12044471 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sumioka A, Imoto S, Martins RN, "et al." |title=XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms. |journal=Biochem. J. |volume=374 |issue= Pt 1 |pages= 261–8 |year= 2003 |pmid= 12780348 |doi= 10.1042/BJ20030489
*cite journal | author=Yoo JC, Chang JR, Kim SH, "et al." |title=NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi. |journal=Exp. Cell Res. |volume=292 |issue= 2 |pages= 393–402 |year= 2004 |pmid= 14697346 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

PBB_Controls
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