S100A5

S100 calcium binding protein A5, also known as S100A5, is a human gene.cite web | title = Entrez Gene: S100A5 S100 calcium binding protein A5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6276| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain.cite web | title = Entrez Gene: S100A5 S100 calcium binding protein A5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6276| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134–40 |year= 1996 |pmid= 8701470 |doi=
*cite journal | author=Schäfer BW, Wicki R, Engelkamp D, "et al." |title=Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. |journal=Genomics |volume=25 |issue= 3 |pages= 638–43 |year= 1995 |pmid= 7759097 |doi=
*cite journal | author=Engelkamp D, Schäfer BW, Mattei MG, "et al." |title=Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6547–51 |year= 1993 |pmid= 8341667 |doi=
*cite journal | author=Ridinger K, Ilg EC, Niggli FK, "et al." |title=Clustered organization of S100 genes in human and mouse. |journal=Biochim. Biophys. Acta |volume=1448 |issue= 2 |pages= 254–63 |year= 1999 |pmid= 9920416 |doi=
*cite journal | author=Schäfer BW, Fritschy JM, Murmann P, "et al." |title=Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily. |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30623–30 |year= 2000 |pmid= 10882717 |doi= 10.1074/jbc.M002260200
*cite journal | author=Bronckart Y, Decaestecker C, Nagy N, "et al." |title=Development and progression of malignancy in human colon tissues are correlated with expression of specific Ca(2+)-binding S100 proteins. |journal=Histol. Histopathol. |volume=16 |issue= 3 |pages= 707–12 |year= 2002 |pmid= 11510959 |doi=
*cite journal | author=Teratani T, Watanabe T, Yamahara K, "et al." |title=Restricted expression of calcium-binding protein S100A5 in human kidney. |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue= 3 |pages= 623–7 |year= 2002 |pmid= 11855835 |doi= 10.1006/bbrc.2002.6494
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chan WY, Xia CL, Dong DC, "et al." |title=Differential expression of S100 proteins in the developing human hippocampus and temporal cortex. |journal=Microsc. Res. Tech. |volume=60 |issue= 6 |pages= 600–13 |year= 2003 |pmid= 12645008 |doi= 10.1002/jemt.10302
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727

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