MAP4K2

Mitogen-activated protein kinase kinase kinase kinase 2, also known as MAP4K2, is a human gene.cite web | title = Entrez Gene: MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5871| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.cite web | title = Entrez Gene: MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5871| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Vionnet N, Stoffel M, Takeda J, "et al." |title=Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. |journal=Nature |volume=356 |issue= 6371 |pages= 721–2 |year= 1992 |pmid= 1570017 |doi= 10.1038/356721a0
*cite journal | author=Matsutani A, Janssen R, Donis-Keller H, Permutt MA |title=A polymorphic (CA)n repeat element maps the human glucokinase gene (GCK) to chromosome 7p. |journal=Genomics |volume=12 |issue= 2 |pages= 319–25 |year= 1992 |pmid= 1740341 |doi=
*cite journal | author=Pombo CM, Kehrl JH, Sánchez I, "et al." |title=Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. |journal=Nature |volume=377 |issue= 6551 |pages= 750–4 |year= 1995 |pmid= 7477268 |doi= 10.1038/377750a0
*cite journal | author=Katz P, Whalen G, Kehrl JH |title=Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center. |journal=J. Biol. Chem. |volume=269 |issue= 24 |pages= 16802–9 |year= 1994 |pmid= 7515885 |doi=
*cite journal | author=Ren M, Zeng J, De Lemos-Chiarandini C, "et al." |title=In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 10 |pages= 5151–5 |year= 1996 |pmid= 8643544 |doi=
*cite journal | author=Guru SC, Agarwal SK, Manickam P, "et al." |title=A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. |journal=Genome Res. |volume=7 |issue= 7 |pages= 725–35 |year= 1997 |pmid= 9253601 |doi=
*cite journal | author=Yuasa T, Ohno S, Kehrl JH, Kyriakis JM |title=Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22681–92 |year= 1998 |pmid= 9712898 |doi=
*cite journal | author=Chadee DN, Yuasa T, Kyriakis JM |title=Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. |journal=Mol. Cell. Biol. |volume=22 |issue= 3 |pages= 737–49 |year= 2002 |pmid= 11784851 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wissing J, Jänsch L, Nimtz M, "et al." |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. |journal=Mol. Cell Proteomics |volume=6 |issue= 3 |pages= 537–47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200

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