RNF111

Ring finger protein 111, also known as RNF111, is a human gene.cite web | title = Entrez Gene: RNF111 ring finger protein 111| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54778| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.cite web | title = Entrez Gene: RNF111 ring finger protein 111| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54778| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Patten I, Placzek M |title=Vertebrate development: Et in Arkadia. |journal=Curr. Biol. |volume=11 |issue= 15 |pages= R616–9 |year= 2001 |pmid= 11516970 |doi=
*cite journal | author=Episkopou V, Arkell R, Timmons PM, "et al." |title=Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. |journal=Nature |volume=410 |issue= 6830 |pages= 825–30 |year= 2001 |pmid= 11298452 |doi= 10.1038/35071095
*cite journal | author=Niederländer C, Walsh JJ, Episkopou V, Jones CM |title=Arkadia enhances nodal-related signalling to induce mesendoderm. |journal=Nature |volume=410 |issue= 6830 |pages= 830–4 |year= 2001 |pmid= 11298453 |doi= 10.1038/35071103
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Koinuma D, Shinozaki M, Komuro A, "et al." |title=Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6458–70 |year= 2004 |pmid= 14657019 |doi= 10.1093/emboj/cdg632
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Liu W, Rui H, Wang J, "et al." |title=Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. |journal=EMBO J. |volume=25 |issue= 8 |pages= 1646–58 |year= 2006 |pmid= 16601693 |doi= 10.1038/sj.emboj.7601057
*cite journal | author=Nagano Y, Mavrakis KJ, Lee KL, "et al." |title=Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling. |journal=J. Biol. Chem. |volume=282 |issue= 28 |pages= 20492–501 |year= 2007 |pmid= 17510063 |doi= 10.1074/jbc.M701294200
*cite journal | author=Levy L, Howell M, Das D, "et al." |title=Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. |journal=Mol. Cell. Biol. |volume=27 |issue= 17 |pages= 6068–83 |year= 2007 |pmid= 17591695 |doi= 10.1128/MCB.00664-07

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