FXYD3

FXYD domain containing ion transport regulator 3, also known as FXYD3, is a human gene.cite web | title = Entrez Gene: FXYD3 FXYD domain containing ion transport regulator 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5349| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene may function as a chloride channel or as a chloride channel regulator. Two transcript variants encode two different isoforms of the protein; in addition, transcripts utilizing alternative polyA signals have been described in the literature.cite web | title = Entrez Gene: FXYD3 FXYD domain containing ion transport regulator 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5349| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Morrison BW, Moorman JR, Kowdley GC, "et al." |title=Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes. |journal=J. Biol. Chem. |volume=270 |issue= 5 |pages= 2176–82 |year= 1995 |pmid= 7836447 |doi=
*cite journal | author=Sweadner KJ, Rael E |title=The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. |journal=Genomics |volume=68 |issue= 1 |pages= 41–56 |year= 2001 |pmid= 10950925 |doi= 10.1006/geno.2000.6274
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Crowell KJ, Franzin CM, Koltay A, "et al." |title=Expression and characterization of the FXYD ion transport regulators for NMR structural studies in lipid micelles and lipid bilayers. |journal=Biochim. Biophys. Acta |volume=1645 |issue= 1 |pages= 15–21 |year= 2003 |pmid= 12535606 |doi=
*cite journal | author=Grzmil M, Voigt S, Thelen P, "et al." |title=Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells. |journal=Int. J. Oncol. |volume=24 |issue= 1 |pages= 97–105 |year= 2004 |pmid= 14654946 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kayed H, Kleeff J, Kolb A, "et al." |title=FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth. |journal=Int. J. Cancer |volume=118 |issue= 1 |pages= 43–54 |year= 2005 |pmid= 16003754 |doi= 10.1002/ijc.21257
*cite journal | author=Franzin CM, Yu J, Thai K, "et al." |title=Correlation of gene and protein structures in the FXYD family proteins. |journal=J. Mol. Biol. |volume=354 |issue= 4 |pages= 743–50 |year= 2006 |pmid= 16288923 |doi= 10.1016/j.jmb.2005.10.018
*cite journal | author=Bibert S, Roy S, Schaer D, "et al." |title=Structural and functional properties of two human FXYD3 (Mat-8) isoforms. |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39142–51 |year= 2007 |pmid= 17077088 |doi= 10.1074/jbc.M605221200
*cite journal | author=Arimochi J, Ohashi-Kobayashi A, Maeda M |title=Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells. |journal=Biol. Pharm. Bull. |volume=30 |issue= 4 |pages= 648–54 |year= 2007 |pmid= 17409496 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes