FXYD1

FXYD domain containing ion transport regulator 1 (phospholemman), also known as FXYD1, is a human gene.cite web | title = Entrez Gene: FXYD1 FXYD domain containing ion transport regulator 1 (phospholemman)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5348| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature.cite web | title = Entrez Gene: FXYD1 FXYD domain containing ion transport regulator 1 (phospholemman)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5348| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Walaas SI, Czernik AJ, Olstad OK, "et al." |title=Protein kinase C and cyclic AMP-dependent protein kinase phosphorylate phospholemman, an insulin and adrenaline-regulated membrane phosphoprotein, at specific sites in the carboxy terminal domain. |journal=Biochem. J. |volume=304 ( Pt 2) |issue= |pages= 635–40 |year= 1995 |pmid= 7999001 |doi=
*cite journal | author=Chen LS, Lo CF, Numann R, Cuddy M |title=Characterization of the human and rat phospholemman (PLM) cDNAs and localization of the human PLM gene to chromosome 19q13.1. |journal=Genomics |volume=41 |issue= 3 |pages= 435–43 |year= 1997 |pmid= 9169143 |doi= 10.1006/geno.1997.4665
*cite journal | author=Neumann J, Maas R, Bokník P, "et al." |title=Pharmacological characterization of protein phosphatase activities in preparations from failing human hearts. |journal=J. Pharmacol. Exp. Ther. |volume=289 |issue= 1 |pages= 188–93 |year= 1999 |pmid= 10087003 |doi=
*cite journal | author=Mounsey JP, John JE, Helmke SM, "et al." |title=Phospholemman is a substrate for myotonic dystrophy protein kinase. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23362–7 |year= 2000 |pmid= 10811636 |doi= 10.1074/jbc.M000899200
*cite journal | author=Sweadner KJ, Rael E |title=The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. |journal=Genomics |volume=68 |issue= 1 |pages= 41–56 |year= 2001 |pmid= 10950925 |doi= 10.1006/geno.2000.6274
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Crowell KJ, Franzin CM, Koltay A, "et al." |title=Expression and characterization of the FXYD ion transport regulators for NMR structural studies in lipid micelles and lipid bilayers. |journal=Biochim. Biophys. Acta |volume=1645 |issue= 1 |pages= 15–21 |year= 2003 |pmid= 12535606 |doi=
*cite journal | author=Fuller W, Eaton P, Bell JR, Shattock MJ |title=Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase. |journal=FASEB J. |volume=18 |issue= 1 |pages= 197–9 |year= 2004 |pmid= 14597563 |doi= 10.1096/fj.03-0213fje
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Franzin CM, Yu J, Thai K, "et al." |title=Correlation of gene and protein structures in the FXYD family proteins. |journal=J. Mol. Biol. |volume=354 |issue= 4 |pages= 743–50 |year= 2006 |pmid= 16288923 |doi= 10.1016/j.jmb.2005.10.018
*cite journal | author=Wang J, Zhang XQ, Ahlers BA, "et al." |title=Cytoplasmic tail of phospholemman interacts with the intracellular loop of the cardiac Na+/Ca2+ exchanger. |journal=J. Biol. Chem. |volume=281 |issue= 42 |pages= 32004–14 |year= 2006 |pmid= 16921169 |doi= 10.1074/jbc.M606876200
*cite journal | author=Deng V, Matagne V, Banine F, "et al." |title=FXYD1 is an MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice. |journal=Hum. Mol. Genet. |volume=16 |issue= 6 |pages= 640–50 |year= 2007 |pmid= 17309881 |doi= 10.1093/hmg/ddm007

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