ZRF1

Zuotin related factor 1, also known as ZRF1, is a human gene.cite web | title = Entrez Gene: ZRF1 zuotin related factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27000| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.cite web | title = Entrez Gene: ZRF1 zuotin related factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27000| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Matsumoto-Taniura N, Pirollet F, Monroe R, "et al." |title=Identification of novel M phase phosphoproteins by expression cloning. |journal=Mol. Biol. Cell |volume=7 |issue= 9 |pages= 1455–69 |year= 1997 |pmid= 8885239 |doi=
*cite journal | author=Resto VA, Caballero OL, Buta MR, "et al." |title=A putative oncogenic role for MPP11 in head and neck squamous cell cancer. |journal=Cancer Res. |volume=60 |issue= 19 |pages= 5529–35 |year= 2000 |pmid= 11034098 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Greiner J, Ringhoffer M, Taniguchi M, "et al." |title=Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia. |journal=Int. J. Cancer |volume=106 |issue= 2 |pages= 224–31 |year= 2003 |pmid= 12800198 |doi= 10.1002/ijc.11200
*cite journal | author=Greiner J, Ringhoffer M, Taniguchi M, "et al." |title=mRNA expression of leukemia-associated antigens in patients with acute myeloid leukemia for the development of specific immunotherapies. |journal=Int. J. Cancer |volume=108 |issue= 5 |pages= 704–11 |year= 2004 |pmid= 14696097 |doi= 10.1002/ijc.11623
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Hundley HA, Walter W, Bairstow S, Craig EA |title=Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous. |journal=Science |volume=308 |issue= 5724 |pages= 1032–4 |year= 2005 |pmid= 15802566 |doi= 10.1126/science.1109247
*cite journal | author=Otto H, Conz C, Maier P, "et al." |title=The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 29 |pages= 10064–9 |year= 2005 |pmid= 16002468 |doi= 10.1073/pnas.0504400102
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

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