FBXL2

F-box and leucine-rich repeat protein 2, also known as FBXL2, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats.cite web | title = Entrez Gene: FBXL2 F-box and leucine-rich repeat protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25827| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ye J |title=Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus. |journal=PLoS Pathog. |volume=3 |issue= 8 |pages= e108 |year= 2007 |pmid= 17784784 |doi= 10.1371/journal.ppat.0030108
*cite journal | author=Ilyin GP, Rialland M, Glaise D, Guguen-Guillouzo C |title=Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats. |journal=FEBS Lett. |volume=459 |issue= 1 |pages= 75–9 |year= 1999 |pmid= 10508920 |doi=10.1016/S0014-5793(99)01211-9
*cite journal | author=Cenciarelli C, Chiaur DS, Guardavaccaro D, "et al." |title=Identification of a family of human F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1177–9 |year= 1999 |pmid= 10531035 |doi= 10.1016/S0960-9822(00)80020-2
*cite journal | author=Winston JT, Koepp DM, Zhu C, "et al." |title=A family of mammalian F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1180–2 |year= 1999 |pmid= 10531037 |doi= 10.1016/S0960-9822(00)80021-4
*cite journal | author=Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C |title=cDNA cloning and expression analysis of new members of the mammalian F-box protein family. |journal=Genomics |volume=67 |issue= 1 |pages= 40–7 |year= 2001 |pmid= 10945468 |doi= 10.1006/geno.2000.6211
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wang C, Gale M, Keller BC, "et al." |title=Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. |journal=Mol. Cell |volume=18 |issue= 4 |pages= 425–34 |year= 2005 |pmid= 15893726 |doi= 10.1016/j.molcel.2005.04.004
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes