- ICK (gene)
Intestinal cell (MAK-like) kinase, also known as ICK, is a human
gene .cite web | title = Entrez Gene: ICK intestinal cell (MAK-like) kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22858| accessdate = ]PBB_Summary
section_title =
summary_text = Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified.cite web | title = Entrez Gene: ICK intestinal cell (MAK-like) kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22858| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 1 |pages= 63–70 |year= 1999 |pmid= 10231032 |doi=
*cite journal | author=Togawa K, Yan YX, Inomoto T, "et al." |title=Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases. |journal=J. Cell. Physiol. |volume=183 |issue= 1 |pages= 129–39 |year= 2000 |pmid= 10699974 |doi= 10.1002/(SICI)1097-4652(200004)183:1<129::AID-JCP15>3.0.CO;2-S |doilabel=10.1002/(SICI)1097-4652(200004)183:1129::AID-JCP153.0.CO;2-S
*cite journal | author=Yang T, Jiang Y, Chen J |title=The identification and subcellular localization of human MRK. |journal=Biomol. Eng. |volume=19 |issue= 1 |pages= 1–4 |year= 2002 |pmid= 12103360 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Fu Z, Schroeder MJ, Shabanowitz J, "et al." |title=Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase. |journal=Mol. Cell. Biol. |volume=25 |issue= 14 |pages= 6047–64 |year= 2005 |pmid= 15988018 |doi= 10.1128/MCB.25.14.6047-6064.2005
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406PBB_Controls
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