CGB2 (gene)

Chorionic gonadotropin, beta polypeptide 2, also known as CGB2, is a human gene.cite web | title = Entrez Gene: CGB2 chorionic gonadotropin, beta polypeptide 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114336| accessdate = ]

PBB_Summary
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summary_text = The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits.cite web | title = Entrez Gene: CGB2 chorionic gonadotropin, beta polypeptide 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114336| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bo M, Boime I |title=Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo. |journal=J. Biol. Chem. |volume=267 |issue= 5 |pages= 3179–84 |year= 1992 |pmid= 1371113 |doi=
*cite journal | author=Policastro PF, Daniels-McQueen S, Carle G, Boime I |title=A map of the hCG beta-LH beta gene cluster. |journal=J. Biol. Chem. |volume=261 |issue= 13 |pages= 5907–16 |year= 1986 |pmid= 2422163 |doi=
*cite journal | author=Policastro P, Ovitt CE, Hoshina M, "et al." |title=The beta subunit of human chorionic gonadotropin is encoded by multiple genes. |journal=J. Biol. Chem. |volume=258 |issue= 19 |pages= 11492–9 |year= 1983 |pmid= 6194155 |doi=
*cite journal | author=Julier C, Weil D, Couillin P, "et al." |title=The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19. |journal=Hum. Genet. |volume=67 |issue= 2 |pages= 174–7 |year= 1984 |pmid= 6204923 |doi=
*cite journal | author=Talmadge K, Boorstein WR, Fiddes JC |title=The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone. |journal=DNA |volume=2 |issue= 4 |pages= 281–9 |year= 1984 |pmid= 6319099 |doi=
*cite journal | author=Talmadge K, Vamvakopoulos NC, Fiddes JC |title=Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. |journal=Nature |volume=307 |issue= 5946 |pages= 37–40 |year= 1984 |pmid= 6690982 |doi=
*cite journal | author=Dirnhofer S, Hermann M, Hittmair A, "et al." |title=Expression of the human chorionic gonadotropin-beta gene cluster in human pituitaries and alternate use of exon 1. |journal=J. Clin. Endocrinol. Metab. |volume=81 |issue= 12 |pages= 4212–7 |year= 1997 |pmid= 8954017 |doi=
*cite journal | author=Venter JC, Adams MD, Myers EW, "et al." |title=The sequence of the human genome. |journal=Science |volume=291 |issue= 5507 |pages= 1304–51 |year= 2001 |pmid= 11181995 |doi= 10.1126/science.1058040
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hallast P, Rull K, Laan M |title=The evolution and genomic landscape of CGB1 and CGB2 genes. |journal=Mol. Cell. Endocrinol. |volume=260-262 |issue= |pages= 2–11 |year= 2007 |pmid= 17055150 |doi= 10.1016/j.mce.2005.11.049

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