Heterogeneous nuclear ribonucleoprotein D-like, also known as HNRPDL, is a human gene.cite web | title = Entrez Gene: HNRPDL heterogeneous nuclear ribonucleoprotein D-like| url =| accessdate = ]

section_title =
summary_text = This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Two alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein encoded by this gene is similar to its family member HNRPD.cite web | title = Entrez Gene: HNRPDL heterogeneous nuclear ribonucleoprotein D-like| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Doi A, Shiosaka T, Takaoka Y, "et al." |title=Molecular cloning of the cDNA encoding A + U-rich element RNA binding factor. |journal=Biochim. Biophys. Acta |volume=1396 |issue= 1 |pages= 51–6 |year= 1998 |pmid= 9524220 |doi=
*cite journal | author=Tsuchiya N, Kamei D, Takano A, "et al." |title=Cloning and characterization of a cDNA encoding a novel heterogeneous nuclear ribonucleoprotein-like protein and its expression in myeloid leukemia cells. |journal=J. Biochem. |volume=123 |issue= 3 |pages= 499–507 |year= 1998 |pmid= 9538234 |doi=
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Kamei D, Tsuchiya N, Yamazaki M, "et al." |title=Two forms of expression and genomic structure of the human heterogeneous nuclear ribonucleoprotein D-like JKTBP gene (HNRPDL). |journal=Gene |volume=228 |issue= 1-2 |pages= 13–22 |year= 1999 |pmid= 10072754 |doi=
*cite journal | author=Kawamura H, Tomozoe Y, Akagi T, "et al." |title=Identification of the nucleocytoplasmic shuttling sequence of heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its interaction with mRNA. |journal=J. Biol. Chem. |volume=277 |issue= 4 |pages= 2732–9 |year= 2002 |pmid= 11705999 |doi= 10.1074/jbc.M108477200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Boopathi E, Lenka N, Prabu SK, "et al." |title=Regulation of murine cytochrome c oxidase Vb gene expression during myogenesis: YY-1 and heterogeneous nuclear ribonucleoprotein D-like protein (JKTBP1) reciprocally regulate transcription activity by physical interaction with the BERF-1/ZBP-89 factor. |journal=J. Biol. Chem. |volume=279 |issue= 34 |pages= 35242–54 |year= 2005 |pmid= 15190078 |doi= 10.1074/jbc.M403160200
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Reboll MR, Oumard A, Gazdag AC, "et al." |title=NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element. |journal=RNA |volume=13 |issue= 8 |pages= 1328–40 |year= 2007 |pmid= 17592041 |doi= 10.1261/rna.545407

update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”