SOCS6

Suppressor of cytokine signaling 6, also known as SOCS6, is a human gene.cite web | title = Entrez Gene: SOCS6 suppressor of cytokine signaling 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9306| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.cite web | title = Entrez Gene: SOCS6 suppressor of cytokine signaling 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9306| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kile BT, Schulman BA, Alexander WS, "et al." |title=The SOCS box: a tale of destruction and degradation. |journal=Trends Biochem. Sci. |volume=27 |issue= 5 |pages= 235–41 |year= 2002 |pmid= 12076535 |doi=
*cite journal | author=Masuhara M, Sakamoto H, Matsumoto A, "et al." |title=Cloning and characterization of novel CIS family genes. |journal=Biochem. Biophys. Res. Commun. |volume=239 |issue= 2 |pages= 439–46 |year= 1997 |pmid= 9344848 |doi= 10.1006/bbrc.1997.7484
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=
*cite journal | author=Mooney RA, Senn J, Cameron S, "et al." |title=Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 25889–93 |year= 2001 |pmid= 11342531 |doi= 10.1074/jbc.M010579200
*cite journal | author=Krebs DL, Uren RT, Metcalf D, "et al." |title=SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4567–78 |year= 2002 |pmid= 12052866 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bayle J, Letard S, Frank R, "et al." |title=Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12249–59 |year= 2004 |pmid= 14707129 |doi= 10.1074/jbc.M313381200
*cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, "et al." |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776
*cite journal | author=Bayle J, Lopez S, Iwaï K, "et al." |title=The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins. |journal=FEBS Lett. |volume=580 |issue= 11 |pages= 2609–14 |year= 2006 |pmid= 16643902 |doi= 10.1016/j.febslet.2006.03.093
*cite journal | author=Hwang MN, Ha TH, Park J, "et al." |title=Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcdelta activation. |journal=Biochem. Biophys. Res. Commun. |volume=354 |issue= 1 |pages= 184–9 |year= 2007 |pmid= 17210122 |doi= 10.1016/j.bbrc.2006.12.175
*cite journal | author=Hwang MN, Min CH, Kim HS, "et al." |title=The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels. |journal=Biochem. Biophys. Res. Commun. |volume=360 |issue= 2 |pages= 333–8 |year= 2007 |pmid= 17603019 |doi= 10.1016/j.bbrc.2007.06.062

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