STARD5

START domain containing 5, also known as STARD5, is a human gene.cite web | title = Entrez Gene: STARD5 START domain containing 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80765| accessdate = ]

PBB_Summary
section_title =
summary_text = Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD5 (Soccio et al., 2002). [supplied by OMIM] cite web | title = Entrez Gene: STARD5 START domain containing 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80765| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Strauss JF, Kishida T, Christenson LK, "et al." |title=START domain proteins and the intracellular trafficking of cholesterol in steroidogenic cells. |journal=Mol. Cell. Endocrinol. |volume=202 |issue= 1-2 |pages= 59–65 |year= 2004 |pmid= 12770731 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Wines ME, Lee L, Katari MS, "et al." |title=Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis. |journal=Genomics |volume=72 |issue= 1 |pages= 88–98 |year= 2001 |pmid= 11247670 |doi= 10.1006/geno.2000.6466
*cite journal | author=Soccio RE, Adams RM, Romanowski MJ, "et al." |title=The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 10 |pages= 6943–8 |year= 2002 |pmid= 12011452 |doi= 10.1073/pnas.052143799
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Soccio RE, Adams RM, Maxwell KN, Breslow JL |title=Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress. |journal=J. Biol. Chem. |volume=280 |issue= 19 |pages= 19410–8 |year= 2005 |pmid= 15760897 |doi= 10.1074/jbc.M501778200
*cite journal | author=Rodriguez-Agudo D, Ren S, Hylemon PB, "et al." |title=Human StarD5, a cytosolic StAR-related lipid binding protein. |journal=J. Lipid Res. |volume=46 |issue= 8 |pages= 1615–23 |year= 2005 |pmid= 15897605 |doi= 10.1194/jlr.M400501-JLR200
*cite journal | author=Rodriguez-Agudo D, Ren S, Hylemon PB, "et al." |title=Localization of StarD5 cholesterol binding protein. |journal=J. Lipid Res. |volume=47 |issue= 6 |pages= 1168–75 |year= 2006 |pmid= 16534142 |doi= 10.1194/jlr.M500447-JLR200

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