UGT8

UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase), also known as UGT8, is a human gene.cite web | title = Entrez Gene: UGT8 UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7368| accessdate = ]

PBB_Summary
section_title =
summary_text = Galactocerebrosides are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system and are also present in small amounts in kidney. The key enzymatic step in the biosynthesis of galactocerebrosides consists of the transfer of galactose to ceramide catalyzed by UDP-galactose ceramide galactosyltransferase (CGT, EC 2.4.1.45). The enzyme encoded by the CGT gene is the first involved in complex lipid biosynthesis in the myelinating oligodendrocyte. [supplied by OMIM] cite web | title = Entrez Gene: UGT8 UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7368| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yahi N, Spitalnik SL, Stefano KA, "et al." |title=Interferon-gamma decreases cell surface expression of galactosyl ceramide, the receptor for HIV-1 GP120 on human colonic epithelial cells. |journal=Virology |volume=204 |issue= 2 |pages= 550–7 |year= 1994 |pmid= 7941321 |doi= 10.1006/viro.1994.1568
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Bhat S, Mettus RV, Reddy EP, "et al." |title=The galactosyl ceramide/sulfatide receptor binding region of HIV-1 gp120 maps to amino acids 206-275. |journal=AIDS Res. Hum. Retroviruses |volume=9 |issue= 2 |pages= 175–81 |year= 1993 |pmid= 8457384 |doi=
*cite journal | author=Bosio A, Binczek E, Le Beau MM, "et al." |title=The human gene CGT encoding the UDP-galactose ceramide galactosyl transferase (cerebroside synthase): cloning, characterization, and assignment to human chromosome 4, band q26. |journal=Genomics |volume=34 |issue= 1 |pages= 69–75 |year= 1996 |pmid= 8661025 |doi= 10.1006/geno.1996.0242
*cite journal | author=Kapitonov D, Yu RK |title=Cloning, characterization, and expression of human ceramide galactosyltransferase cDNA. |journal=Biochem. Biophys. Res. Commun. |volume=232 |issue= 2 |pages= 449–53 |year= 1997 |pmid= 9125199 |doi= 10.1006/bbrc.1997.6240
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Sprong H, Kruithof B, Leijendekker R, "et al." |title=UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25880–8 |year= 1998 |pmid= 9748263 |doi=
*cite journal | author=Iida A, Saito S, Sekine A, "et al." |title=Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8. |journal=J. Hum. Genet. |volume=47 |issue= 10 |pages= 505–10 |year= 2002 |pmid= 12376738 |doi= 10.1007/s100380200075
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sprong H, Degroote S, Nilsson T, "et al." |title=Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum. |journal=Mol. Biol. Cell |volume=14 |issue= 8 |pages= 3482–93 |year= 2004 |pmid= 12925779 |doi= 10.1091/mbc.E03-03-0130
*cite journal | author=Tencomnao T, Kapitonov D, Bieberich E, Yu RK |title=Transcriptional regulation of the human UDP-galactose:ceramide galactosyltransferase (hCGT) gene expression: functional role of GC-box and CRE. |journal=Glycoconj. J. |volume=20 |issue= 5 |pages= 339–51 |year= 2005 |pmid= 15229398 |doi= 10.1023/B:GLYC.0000033630.58533.16
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lebea PJ, Pretorius PJ |title=The molecular relationship between deficient UDP-galactose uridyl transferase (GALT) and ceramide galactosyltransferase (CGT) enzyme function: a possible cause for poor long-term prognosis in classic galactosemia. |journal=Med. Hypotheses |volume=65 |issue= 6 |pages= 1051–7 |year= 2006 |pmid= 16125333 |doi= 10.1016/j.mehy.2005.06.025

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