SEPW1

Selenoprotein W, 1, also known as SEPW1, is a human gene.cite web | title = Entrez Gene: SEPW1 selenoprotein W, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6415| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34.cite web | title = Entrez Gene: SEPW1 selenoprotein W, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6415| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Whanger PD |title=Selenoprotein W: a review. |journal=Cell. Mol. Life Sci. |volume=57 |issue= 13-14 |pages= 1846–52 |year= 2001 |pmid= 11215511 |doi=
*cite journal | author=Yeh JY, Beilstein MA, Andrews JS, Whanger PD |title=Tissue distribution and influence of selenium status on levels of selenoprotein W. |journal=FASEB J. |volume=9 |issue= 5 |pages= 392–6 |year= 1995 |pmid= 7896009 |doi=
*cite journal | author=Gu QP, Beilstein MA, Vendeland SC, "et al." |title=Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species. |journal=Gene |volume=193 |issue= 2 |pages= 187–96 |year= 1997 |pmid= 9256076 |doi=
*cite journal | author=Smith JS, Tachibana I, Pohl U, "et al." |title=A transcript map of the chromosome 19q-arm glioma tumor suppressor region. |journal=Genomics |volume=64 |issue= 1 |pages= 44–50 |year= 2000 |pmid= 10708517 |doi= 10.1006/geno.1999.6101
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kryukov GV, Castellano S, Novoselov SV, "et al." |title=Characterization of mammalian selenoproteomes. |journal=Science |volume=300 |issue= 5624 |pages= 1439–43 |year= 2003 |pmid= 12775843 |doi= 10.1126/science.1083516
*cite journal | author=Bellingham J, Gregory-Evans K, Fox MF, Gregory-Evans CY |title=Gene structure and tissue expression of human selenoprotein W, SEPW1, and identification of a retroprocessed pseudogene, SEPW1P. |journal=Biochim. Biophys. Acta |volume=1627 |issue= 2-3 |pages= 140–6 |year= 2003 |pmid= 12818432 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Pagmantidis V, Bermano G, Villette S, "et al." |title=Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon. |journal=FEBS Lett. |volume=579 |issue= 3 |pages= 792–6 |year= 2005 |pmid= 15670848 |doi= 10.1016/j.febslet.2004.12.042
*cite journal | author=Kim YJ, Chai YG, Ryu JC |title=Selenoprotein W as molecular target of methylmercury in human neuronal cells is down-regulated by GSH depletion. |journal=Biochem. Biophys. Res. Commun. |volume=330 |issue= 4 |pages= 1095–102 |year= 2005 |pmid= 15823556 |doi= 10.1016/j.bbrc.2005.03.080

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