- PLXNA2
Plexin A2, also known as PLXNA2, is a human
gene .cite web | title = Entrez Gene: PLXNA2 plexin A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5362| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.cite web | title = Entrez Gene: PLXNA2 plexin A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5362| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Negishi M, Oinuma I, Katoh H |title=Plexins: axon guidance and signal transduction. |journal=Cell. Mol. Life Sci. |volume=62 |issue= 12 |pages= 1363–71 |year= 2005 |pmid= 15818466 |doi= 10.1007/s00018-005-5018-2
*cite journal | author=Maestrini E, Tamagnone L, Longati P, "et al." |title=A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 2 |pages= 674–8 |year= 1996 |pmid= 8570614 |doi=
*cite journal | author=Seki N, Ohira M, Nagase T, "et al." |title=Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. |journal=DNA Res. |volume=4 |issue= 5 |pages= 345–9 |year= 1998 |pmid= 9455484 |doi=
*cite journal | author=Tamagnone L, Artigiani S, Chen H, "et al." |title=Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. |journal=Cell |volume=99 |issue= 1 |pages= 71–80 |year= 1999 |pmid= 10520995 |doi=
*cite journal | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Mah S, Nelson MR, Delisi LE, "et al." |title=Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia. |journal=Mol. Psychiatry |volume=11 |issue= 5 |pages= 471–8 |year= 2006 |pmid= 16402134 |doi= 10.1038/sj.mp.4001785
*cite journal | author=Fujii T, Iijima Y, Kondo H, "et al." |title=Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population. |journal=Prog. Neuropsychopharmacol. Biol. Psychiatry |volume=31 |issue= 4 |pages= 873–7 |year= 2007 |pmid= 17346868 |doi= 10.1016/j.pnpbp.2007.01.027PBB_Controls
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