MDFI

MyoD family inhibitor, also known as MDFI, is a human gene.cite web | title = Entrez Gene: MDFI MyoD family inhibitor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4188| accessdate = ]

PBB_Summary
section_title =
summary_text = This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interfers with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures.cite web | title = Entrez Gene: MDFI MyoD family inhibitor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4188| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chen CM, Kraut N, Groudine M, Weintraub H |title=I-mf, a novel myogenic repressor, interacts with members of the MyoD family. |journal=Cell |volume=86 |issue= 5 |pages= 731–41 |year= 1996 |pmid= 8797820 |doi=
*cite journal | author=Kraut N |title=The gene encoding I-mf (Mdfi) maps to human chromosome 6p21 and mouse chromosome 17. |journal=Mamm. Genome |volume=8 |issue= 8 |pages= 618–9 |year= 1997 |pmid= 9250874 |doi=
*cite journal | author=Kraut N, Snider L, Chen CM, "et al." |title=Requirement of the mouse I-mfa gene for placental development and skeletal patterning. |journal=EMBO J. |volume=17 |issue= 21 |pages= 6276–88 |year= 1999 |pmid= 9799236 |doi= 10.1093/emboj/17.21.6276
*cite journal | author=Snider L, Thirlwell H, Miller JR, "et al." |title=Inhibition of Tcf3 binding by I-mfa domain proteins. |journal=Mol. Cell. Biol. |volume=21 |issue= 5 |pages= 1866–73 |year= 2001 |pmid= 11238923 |doi= 10.1128/MCB.21.5.1866-1873.2001
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ma R, Rundle D, Jacks J, "et al." |title=Inhibitor of myogenic family, a novel suppressor of store-operated currents through an interaction with TRPC1. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52763–72 |year= 2004 |pmid= 14530267 |doi= 10.1074/jbc.M309610200
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Mizugishi K, Hatayama M, Tohmonda T, "et al." |title=Myogenic repressor I-mfa interferes with the function of Zic family proteins. |journal=Biochem. Biophys. Res. Commun. |volume=320 |issue= 1 |pages= 233–40 |year= 2004 |pmid= 15207726 |doi= 10.1016/j.bbrc.2004.05.158
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032

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