MAN2A1

Mannosidase, alpha, class 2A, member 1, also known as MAN2A1, is a human gene.cite web | title = Entrez Gene: MAN2A1 mannosidase, alpha, class 2A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4124| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.cite web | title = Entrez Gene: MAN2A1 mannosidase, alpha, class 2A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4124| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Land A, Braakman I |title=Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum. |journal=Biochimie |volume=83 |issue= 8 |pages= 783–90 |year= 2001 |pmid= 11530211 |doi=
*cite journal | author=Dedera DA, Gu RL, Ratner L |title=Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function. |journal=Virology |volume=187 |issue= 1 |pages= 377–82 |year= 1992 |pmid= 1736542 |doi=
*cite journal | author=Moremen KW, Robbins PW |title=Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans. |journal=J. Cell Biol. |volume=115 |issue= 6 |pages= 1521–34 |year= 1992 |pmid= 1757461 |doi=
*cite journal | author=Moremen KW, Touster O, Robbins PW |title=Novel purification of the catalytic domain of Golgi alpha-mannosidase II. Characterization and comparison with the intact enzyme. |journal=J. Biol. Chem. |volume=266 |issue= 25 |pages= 16876–85 |year= 1991 |pmid= 1885615 |doi=
*cite journal | author=Kalyanaraman VS, Rodriguez V, Veronese F, "et al." |title=Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1. |journal=AIDS Res. Hum. Retroviruses |volume=6 |issue= 3 |pages= 371–80 |year= 1990 |pmid= 2187500 |doi=
*cite journal | author=Shimizu H, Tsuchie H, Honma H, "et al." |title=Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins. |journal=Jpn. J. Med. Sci. Biol. |volume=43 |issue= 3 |pages= 75–87 |year= 1991 |pmid= 2283726 |doi=
*cite journal | author=Leonard CK, Spellman MW, Riddle L, "et al." |title=Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells. |journal=J. Biol. Chem. |volume=265 |issue= 18 |pages= 10373–82 |year= 1990 |pmid= 2355006 |doi=
*cite journal | author=Pal R, Hoke GM, Sarngadharan MG |title=Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 9 |pages= 3384–8 |year= 1989 |pmid= 2541446 |doi=
*cite journal | author=Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP |title=Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport. |journal=J. Virol. |volume=63 |issue= 6 |pages= 2452–6 |year= 1989 |pmid= 2542563 |doi=
*cite journal | author=Kozarsky K, Penman M, Basiripour L, "et al." |title=Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein. |journal=J. Acquir. Immune Defic. Syndr. |volume=2 |issue= 2 |pages= 163–9 |year= 1989 |pmid= 2649653 |doi=
*cite journal | author=Robinson WE, Montefiori DC, Mitchell WM |title=Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis. |journal=AIDS Res. Hum. Retroviruses |volume=3 |issue= 3 |pages= 265–82 |year= 1988 |pmid= 2829950 |doi=
*cite journal | author=Blough HA, Pauwels R, De Clercq E, "et al." |title=Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins. |journal=Biochem. Biophys. Res. Commun. |volume=141 |issue= 1 |pages= 33–8 |year= 1987 |pmid= 3099781 |doi=
*cite journal | author=Montefiori DC, Robinson WE, Mitchell WM |title=Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 23 |pages= 9248–52 |year= 1988 |pmid= 3264072 |doi=
*cite journal | author=Moremen KW, Touster O |title=Biosynthesis and modification of Golgi mannosidase II in HeLa and 3T3 cells. |journal=J. Biol. Chem. |volume=260 |issue= 11 |pages= 6654–62 |year= 1985 |pmid= 3922977 |doi=
*cite journal | author=Fenouillet E, Jones I, Powell B, "et al." |title=Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain. |journal=J. Virol. |volume=67 |issue= 1 |pages= 150–60 |year= 1993 |pmid= 8093218 |doi=
*cite journal | author=Yeh JC, Seals JR, Murphy CI, "et al." |title=Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system. |journal=Biochemistry |volume=32 |issue= 41 |pages= 11087–99 |year= 1993 |pmid= 8218172 |doi=
*cite journal | author=Velasco A, Hendricks L, Moremen KW, "et al." |title=Cell type-dependent variations in the subcellular distribution of alpha-mannosidase I and II. |journal=J. Cell Biol. |volume=122 |issue= 1 |pages= 39–51 |year= 1993 |pmid= 8314846 |doi=
*cite journal | author=Misago M, Liao YF, Kudo S, "et al." |title=Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 25 |pages= 11766–70 |year= 1996 |pmid= 8524845 |doi=
*cite journal | author=Bolmstedt A, Sjölander S, Hansen JE, "et al." |title=Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response. |journal=J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. |volume=12 |issue= 3 |pages= 213–20 |year= 1996 |pmid= 8673525 |doi=
*cite journal | author=Hu H, Shioda T, Moriya C, "et al." |title=Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface. |journal=J. Virol. |volume=70 |issue= 11 |pages= 7462–70 |year= 1996 |pmid= 8892864 |doi=

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