LLGL1

Lethal giant larvae homolog 1 (Drosophila), also known as LLGL1, is a human gene.

PBB_Summary
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summary_text = This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17.cite web | title = Entrez Gene: LLGL1 lethal giant larvae homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3996| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Strand D, Unger S, Corvi R, "et al." |title=A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain. |journal=Oncogene |volume=11 |issue= 2 |pages= 291–301 |year= 1995 |pmid= 7542763 |doi=
*cite journal | author=Koyama K, Fukushima Y, Inazawa J, "et al." |title=The human homologue of the murine Llglh gene (LLGL) maps within the Smith-Magenis syndrome region in 17p11.2. |journal=Cytogenet. Cell Genet. |volume=72 |issue= 1 |pages= 78–82 |year= 1996 |pmid= 8565641 |doi=10.1159/000134167
*cite journal | author=Campbell HD, Fountain S, Young IG, "et al." |title=Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL. |journal=Genomics |volume=42 |issue= 1 |pages= 46–54 |year= 1997 |pmid= 9177775 |doi= 10.1006/geno.1997.4709
*cite journal | author=Ludford-Menting MJ, Thomas SJ, Crimeen B, "et al." |title=A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarization. |journal=J. Biol. Chem. |volume=277 |issue= 6 |pages= 4477–84 |year= 2002 |pmid= 11714708 |doi= 10.1074/jbc.M108479200
*cite journal | author=Bi W, Yan J, Stankiewicz P, "et al." |title=Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. |journal=Genome Res. |volume=12 |issue= 5 |pages= 713–28 |year= 2002 |pmid= 11997338 |doi= 10.1101/gr.73702
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yamanaka T, Horikoshi Y, Sugiyama Y, "et al." |title=Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. |journal=Curr. Biol. |volume=13 |issue= 9 |pages= 734–43 |year= 2004 |pmid= 12725730 |doi=10.1016/S0960-9822(03)00244-6
*cite journal | author=Grifoni D, Garoia F, Schimanski CC, "et al." |title=The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo. |journal=Oncogene |volume=23 |issue= 53 |pages= 8688–94 |year= 2004 |pmid= 15467749 |doi= 10.1038/sj.onc.1208023
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Schimanski CC, Schmitz G, Kashyap A, "et al." |title=Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer. |journal=Oncogene |volume=24 |issue= 19 |pages= 3100–9 |year= 2005 |pmid= 15735678 |doi= 10.1038/sj.onc.1208520
*cite journal | author=Kuphal S, Wallner S, Schimanski CC, "et al." |title=Expression of Hugl-1 is strongly reduced in malignant melanoma. |journal=Oncogene |volume=25 |issue= 1 |pages= 103–10 |year= 2006 |pmid= 16170365 |doi= 10.1038/sj.onc.1209008
*cite journal | author=Grifoni D, Garoia F, Bellosta P, "et al." |title=aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia. |journal=Oncogene |volume=26 |issue= 40 |pages= 5960–5 |year= 2007 |pmid= 17369850 |doi= 10.1038/sj.onc.1210389

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