SULF1

Sulfatase 1, also known as SULF1, is a human gene.cite web | title = Entrez Gene: SULF1 sulfatase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23213| accessdate = ]

PBB_Summary
section_title =
summary_text = Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF1, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005). [supplied by OMIM] cite web | title = Entrez Gene: SULF1 sulfatase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23213| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kikuno R, Nagase T, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Morimoto-Tomita M, Uchimura K, Werb Z, "et al." |title=Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49175–85 |year= 2003 |pmid= 12368295 |doi= 10.1074/jbc.M205131200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lai J, Chien J, Staub J, "et al." |title=Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 23107–17 |year= 2003 |pmid= 12686563 |doi= 10.1074/jbc.M302203200
*cite journal | author=Lai JP, Chien JR, Moser DR, "et al." |title=hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling. |journal=Gastroenterology |volume=126 |issue= 1 |pages= 231–48 |year= 2004 |pmid= 14699503 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Li J, Kleeff J, Abiatari I, "et al." |title=Enhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer. |journal=Mol. Cancer |volume=4 |issue= 1 |pages= 14 |year= 2006 |pmid= 15817123 |doi= 10.1186/1476-4598-4-14
*cite journal | author=Dai Y, Yang Y, MacLeod V, "et al." |title=HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. |journal=J. Biol. Chem. |volume=280 |issue= 48 |pages= 40066–73 |year= 2006 |pmid= 16192265 |doi= 10.1074/jbc.M508136200
*cite journal | author=Narita K, Chien J, Mullany SA, "et al." |title=Loss of HSulf-1 expression enhances autocrine signaling mediated by amphiregulin in breast cancer. |journal=J. Biol. Chem. |volume=282 |issue= 19 |pages= 14413–20 |year= 2007 |pmid= 17363371 |doi= 10.1074/jbc.M611395200
*cite journal | author=Backen AC, Cole CL, Lau SC, "et al." |title=Heparan sulphate synthetic and editing enzymes in ovarian cancer. |journal=Br. J. Cancer |volume=96 |issue= 10 |pages= 1544–8 |year= 2007 |pmid= 17437011 |doi= 10.1038/sj.bjc.6603747

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