FGFR1OP

FGFR1 oncogene partner, also known as FGFR1OP, is a human gene.cite web | title = Entrez Gene: FGFR1OP FGFR1 oncogene partner| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11116| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.cite web | title = Entrez Gene: FGFR1OP FGFR1 oncogene partner| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11116| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Reither A, Hehlmann R, Goldman JM, Cross NC |title= [The 8p11 myeloproliferative syndrome] |journal=Med. Klin. (Munich) |volume=94 |issue= 4 |pages= 207–10 |year= 1999 |pmid= 10373756 |doi=
*cite journal | author=Popovici C, Zhang B, Grégoire MJ, "et al." |title=The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1. |journal=Blood |volume=93 |issue= 4 |pages= 1381–9 |year= 1999 |pmid= 9949182 |doi=
*cite journal | author=Guasch G, Ollendorff V, Borg JP, "et al." |title=8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways. |journal=Mol. Cell. Biol. |volume=21 |issue= 23 |pages= 8129–42 |year= 2001 |pmid= 11689702 |doi= 10.1128/MCB.21.23.8129-8142.2001
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Guasch G, Delaval B, Arnoulet C, "et al." |title=FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice. |journal=Blood |volume=103 |issue= 1 |pages= 309–12 |year= 2004 |pmid= 12969958 |doi= 10.1182/blood-2003-05-1690
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Andersen JS, Wilkinson CJ, Mayor T, "et al." |title=Proteomic characterization of the human centrosome by protein correlation profiling. |journal=Nature |volume=426 |issue= 6966 |pages= 570–4 |year= 2003 |pmid= 14654843 |doi= 10.1038/nature02166
*cite journal | author=Brill LM, Salomon AR, Ficarro SB, "et al." |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Yan X, Habedanck R, Nigg EA |title=A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring. |journal=Mol. Biol. Cell |volume=17 |issue= 2 |pages= 634–44 |year= 2006 |pmid= 16314388 |doi= 10.1091/mbc.E05-08-0810
*cite journal | author=Mikolajka A, Yan X, Popowicz GM, "et al." |title=Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization. |journal=J. Mol. Biol. |volume=359 |issue= 4 |pages= 863–75 |year= 2006 |pmid= 16690081 |doi= 10.1016/j.jmb.2006.03.070
*cite journal | author=Mano Y, Takahashi K, Ishikawa N, "et al." |title=Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. |journal=Cancer Sci. |volume=98 |issue= 12 |pages= 1902–13 |year= 2007 |pmid= 17888034 |doi= 10.1111/j.1349-7006.2007.00610.x

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