MRVI1

Murine retrovirus integration site 1 homolog, also known as MRVI1, is a human gene.cite web | title = Entrez Gene: MRVI1 murine retrovirus integration site 1 homolog| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10335| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during myeloid differentiation. Therefore, this gene may be a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcripts have been found for this gene, however, the full-length nature of some variants has not been determined. Of the two characterized variants which encode different isoforms, one initiates translation at a non-AUG start site.cite web | title = Entrez Gene: MRVI1 murine retrovirus integration site 1 homolog| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10335| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Adams MD, Dubnick M, Kerlavage AR, "et al." |title=Sequence identification of 2,375 human brain genes. |journal=Nature |volume=355 |issue= 6361 |pages= 632–4 |year= 1992 |pmid= 1538749 |doi= 10.1038/355632a0
*cite journal | author=Baltensperger K, Chiesi M, Carafoli E |title=Substrates of cGMP kinase in vascular smooth muscle and their role in the relaxation process. |journal=Biochemistry |volume=29 |issue= 41 |pages= 9753–60 |year= 1991 |pmid= 2271613 |doi=
*cite journal | author=Shaughnessy JD, Largaespada DA, Tian E, "et al." |title=Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1. |journal=Oncogene |volume=18 |issue= 12 |pages= 2069–84 |year= 1999 |pmid= 10321731 |doi= 10.1038/sj.onc.1202419
*cite journal | author=Schlossmann J, Ammendola A, Ashman K, "et al." |title=Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta. |journal=Nature |volume=404 |issue= 6774 |pages= 197–201 |year= 2000 |pmid= 10724174 |doi= 10.1038/35004606
*cite journal | author=Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J |title=Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24153–9 |year= 2001 |pmid= 11309393 |doi= 10.1074/jbc.M101530200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Koller A, Schlossmann J, Ashman K, "et al." |title=Association of phospholamban with a cGMP kinase signaling complex. |journal=Biochem. Biophys. Res. Commun. |volume=300 |issue= 1 |pages= 155–60 |year= 2003 |pmid= 12480535 |doi=
*cite journal | author=Fritsch RM, Saur D, Kurjak M, "et al." |title=InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12551–9 |year= 2004 |pmid= 14729908 |doi= 10.1074/jbc.M313365200
*cite journal | author=Casteel DE, Boss GR, Pilz RB |title=Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif. |journal=J. Biol. Chem. |volume=280 |issue= 46 |pages= 38211–8 |year= 2006 |pmid= 16166082 |doi= 10.1074/jbc.M507021200
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Antl M, von Brühl ML, Eiglsperger C, "et al." |title=IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. |journal=Blood |volume=109 |issue= 2 |pages= 552–9 |year= 2007 |pmid= 16990611 |doi= 10.1182/blood-2005-10-026294

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