ITM2A

PBB|geneid=9452

Integral membrane protein 2A, also known as ITM2A, is a human gene.cite web | title = Entrez Gene: ITM2A integral membrane protein 2A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9452| accessdate = ] cite journal | author = Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z | title = Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 14 | pages = 8175–80 | year = 1998 | month = July | pmid = 9653160 | pmc = 20949 | doi = | url = http://www.pnas.org/content/95/14/8175.abstract | issn = ]

Function

The protein encoded by this gene is involved in osteo- and chondrogenic cellular differentiation (the cells which are responsible for the development of bone and cartilage respectively).cite journal | author = Deleersnijder W, Hong G, Cortvrindt R, Poirier C, Tylzanowski P, Pittois K, Van Marck E, Merregaert J | title = Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins | journal = J. Biol. Chem. | volume = 271 | issue = 32 | pages = 19475–82 | year = 1996 | month = August | pmid = 8702637 | doi = 10.1074/jbc.271.32.19475 | url = | issn = ]

ITM2A is also involved in activation of T-cells in the immune systemcite journal | author = Kirchner J, Bevan MJ | title = ITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytes | journal = J. Exp. Med. | volume = 190 | issue = 2 | pages = 217–28 | year = 1999 | month = July | pmid = 10432285 | pmc = 2195576 | doi = 10.1084/jem.190.2.217 | url = | issn = ] and in myocyte differentiation.cite journal | author = Van den Plas D, Merregaert J | title = Constitutive overexpression of the integral membrane protein Itm2A enhances myogenic differentiation of C2C12 cells | journal = Cell Biol. Int. | volume = 28 | issue = 3 | pages = 199–207 | year = 2004 | pmid = 14984746 | doi = 10.1016/j.cellbi.2003.11.019 | url = | issn = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Prashar Y, Weissman SM |title=Analysis of differential gene expression by display of 3' end restriction fragments of cDNAs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 2 |pages= 659–63 |year= 1996 |pmid= 8570611 |doi=
*cite journal | author=Deleersnijder W, Hong G, Cortvrindt R, "et al." |title=Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins. |journal=J. Biol. Chem. |volume=271 |issue= 32 |pages= 19475–82 |year= 1996 |pmid= 8702637 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Mao M, Fu G, Wu JS, "et al." |title=Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 8175–80 |year= 1998 |pmid= 9653160 |doi=
*cite journal | author=Pittois K, Wauters J, Bossuyt P, "et al." |title=Genomic organization and chromosomal localization of the Itm2a gene. |journal=Mamm. Genome |volume=10 |issue= 1 |pages= 54–6 |year= 1999 |pmid= 9892734 |doi=
*cite journal | author=Kirchner J, Bevan MJ |title=ITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytes. |journal=J. Exp. Med. |volume=190 |issue= 2 |pages= 217–28 |year= 1999 |pmid= 10432285 |doi=
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440

External links

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