PSCD3

Pleckstrin homology, Sec7 and coiled-coil domains 3, also known as PSCD3, is a human gene.cite web | title = Entrez Gene: PSCD3 pleckstrin homology, Sec7 and coiled-coil domains 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9265| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.cite web | title = Entrez Gene: PSCD3 pleckstrin homology, Sec7 and coiled-coil domains 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9265| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Klarlund JK, Guilherme A, Holik JJ, "et al." |title=Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. |journal=Science |volume=275 |issue= 5308 |pages= 1927–30 |year= 1997 |pmid= 9072969 |doi=
*cite journal | author=Franco M, Boretto J, Robineau S, "et al." |title=ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 9926–31 |year= 1998 |pmid= 9707577 |doi=
*cite journal | author=Venkateswarlu K, Gunn-Moore F, Oatey PB, "et al." |title=Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain. |journal=Biochem. J. |volume=335 ( Pt 1) |issue= |pages= 139–46 |year= 1998 |pmid= 9742223 |doi=
*cite journal | author=Ogasawara M, Kim SC, Adamik R, "et al." |title=Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3221–30 |year= 2000 |pmid= 10652308 |doi=
*cite journal | author=Nevrivy DJ, Peterson VJ, Avram D, "et al." |title=Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 16827–36 |year= 2000 |pmid= 10828067 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Poirier MB, Hamann G, Domingue ME, "et al." |title=General receptor for phosphoinositides 1, a novel repressor of thyroid hormone receptor action that prevents deoxyribonucleic acid binding. |journal=Mol. Endocrinol. |volume=19 |issue= 8 |pages= 1991–2005 |year= 2005 |pmid= 15878955 |doi= 10.1210/me.2004-0449
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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