CAPN5

Calpain 5, also known as CAPN5, is a human gene.cite web | title = Entrez Gene: CAPN5 calpain 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=726| accessdate = ]

PBB_Summary
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summary_text = Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.cite web | title = Entrez Gene: CAPN5 calpain 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=726| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Vanderklish PW, Bahr BA |title=The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states. |journal=International journal of experimental pathology |volume=81 |issue= 5 |pages= 323–39 |year= 2001 |pmid= 11168679 |doi=
*cite journal | author=Sato K, Kawashima S |title=Calpain function in the modulation of signal transduction molecules. |journal=Biol. Chem. |volume=382 |issue= 5 |pages= 743–51 |year= 2002 |pmid= 11517927 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Dear N, Matena K, Vingron M, Boehm T |title=A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution. |journal=Genomics |volume=45 |issue= 1 |pages= 175–84 |year= 1997 |pmid= 9339374 |doi= 10.1006/geno.1997.4870
*cite journal | author=Mugita N, Kimura Y, Ogawa M, "et al." |title=Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene. |journal=Biochem. Biophys. Res. Commun. |volume=239 |issue= 3 |pages= 845–50 |year= 1997 |pmid= 9367857 |doi= 10.1006/bbrc.1997.7571
*cite journal | author=Matena K, Boehm T, Dear N |title=Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily. |journal=Genomics |volume=48 |issue= 1 |pages= 117–20 |year= 1998 |pmid= 9503024 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Waghray A, Wang DS, McKinsey D, "et al." |title=Molecular cloning and characterization of rat and human calpain-5. |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 1 |pages= 46–51 |year= 2004 |pmid= 15464980 |doi= 10.1016/j.bbrc.2004.09.012
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=González A, Sáez ME, Aragón MJ, "et al." |title=Specific haplotypes of the CALPAIN-5 gene are associated with polycystic ovary syndrome. |journal=Hum. Reprod. |volume=21 |issue= 4 |pages= 943–51 |year= 2006 |pmid= 16396936 |doi= 10.1093/humrep/dei443
*cite journal | author=Sáez ME, Martínez-Larrad MT, Ramírez-Lorca R, "et al." |title=Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels. |journal=BMC Med. Genet. |volume=8 |issue= |pages= 1 |year= 2007 |pmid= 17227582 |doi= 10.1186/1471-2350-8-1

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