GCA (gene)

Grancalcin, EF-hand calcium binding protein, also known as GCA, is a human gene.cite web | title = Entrez Gene: GCA grancalcin, EF-hand calcium binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25801| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.cite web | title = Entrez Gene: GCA grancalcin, EF-hand calcium binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25801| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hansen C, Tarabykina S, la Cour JM, "et al." |title=The PEF family proteins sorcin and grancalcin interact in vivo and in vitro. |journal=FEBS Lett. |volume=545 |issue= 2-3 |pages= 151–4 |year= 2003 |pmid= 12804766 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jia J, Borregaard N, Lollike K, Cygler M |title=Structure of Ca(2+)-loaded human grancalcin. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=57 |issue= Pt 12 |pages= 1843–9 |year= 2002 |pmid= 11717497 |doi=
*cite journal | author=Lollike K, Johnsen AH, Durussel I, "et al." |title=Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 17762–9 |year= 2001 |pmid= 11279160 |doi= 10.1074/jbc.M100965200
*cite journal | author=Jia J, Han Q, Borregaard N, "et al." |title=Crystal structure of human grancalcin, a member of the penta-EF-hand protein family. |journal=J. Mol. Biol. |volume=300 |issue= 5 |pages= 1271–81 |year= 2000 |pmid= 10903868 |doi= 10.1006/jmbi.2000.3925
*cite journal | author=Maki M, Narayana SV, Hitomi K |title=A growing family of the Ca2+-binding proteins with five EF-hand motifs. |journal=Biochem. J. |volume=328 ( Pt 2) |issue= |pages= 718–20 |year= 1998 |pmid= 9441591 |doi=
*cite journal | author=Boyhan A, Casimir CM, French JK, "et al." |title=Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes. |journal=J. Biol. Chem. |volume=267 |issue= 5 |pages= 2928–33 |year= 1992 |pmid= 1737748 |doi=
*cite journal | author=Teahan CG, Totty NF, Segal AW |title=Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils. |journal=Biochem. J. |volume=286 ( Pt 2) |issue= |pages= 549–54 |year= 1992 |pmid= 1530588 |doi=

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