ADH7

Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide, also known as ADH7, is a human gene.cite web | title = Entrez Gene: ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=131| accessdate = ]

PBB_Summary
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summary_text = This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members.cite web | title = Entrez Gene: ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=131| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Xie P, Parsons SH, Speckhard DC, "et al." |title=X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity. |journal=J. Biol. Chem. |volume=272 |issue= 30 |pages= 18558–63 |year= 1997 |pmid= 9228021 |doi=
*cite journal | author=Yokoyama H, Baraona E, Lieber CS |title=Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV (sigma) ADH. |journal=Genomics |volume=31 |issue= 2 |pages= 243–5 |year= 1997 |pmid= 8824810 |doi= 10.1006/geno.1996.0040
*cite journal | author=Satre MA, Zgombić-Knight M, Duester G |title=The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene. |journal=J. Biol. Chem. |volume=269 |issue= 22 |pages= 15606–12 |year= 1994 |pmid= 8195208 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Yokoyama S, Matsuo Y, Ramsbotham R, Yokoyama R |title=Molecular characterization of a class IV human alcohol dehydrogenase gene (ADH7). |journal=FEBS Lett. |volume=351 |issue= 3 |pages= 411–5 |year= 1994 |pmid= 8082805 |doi=
*cite journal | author=Yokoyama H, Baraona E, Lieber CS |title=Molecular cloning of human class IV alcohol dehydrogenase cDNA. |journal=Biochem. Biophys. Res. Commun. |volume=203 |issue= 1 |pages= 219–24 |year= 1994 |pmid= 8074657 |doi= 10.1006/bbrc.1994.2170
*cite journal | author=Farrés J, Moreno A, Crosas B, "et al." |title=Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach. cDNA sequence and structure/function relationships. |journal=Eur. J. Biochem. |volume=224 |issue= 2 |pages= 549–57 |year= 1994 |pmid= 7925371 |doi=
*cite journal | author=Zgombić-Knight M, Foglio MH, Duester G |title=Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro. |journal=J. Biol. Chem. |volume=270 |issue= 9 |pages= 4305–11 |year= 1995 |pmid= 7876191 |doi=
*cite journal | author=Kedishvili NY, Bosron WF, Stone CL, "et al." |title=Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes. |journal=J. Biol. Chem. |volume=270 |issue= 8 |pages= 3625–30 |year= 1995 |pmid= 7876099 |doi=
*cite journal | author=Cheung B, Anderson JK, Holmes RS, Beacham IR |title=Human stomach class IV alcohol dehydrogenase: molecular genetic analysis. |journal=Alcohol. Clin. Exp. Res. |volume=19 |issue= 1 |pages= 185–6 |year= 1995 |pmid= 7771649 |doi=
*cite journal | author=Parés X, Cederlund E, Moreno A, "et al." |title=Class IV alcohol dehydrogenase (the gastric enzyme). Structural analysis of human sigma sigma-ADH reveals class IV to be variable and confirms the presence of a fifth mammalian alcohol dehydrogenase class. |journal=FEBS Lett. |volume=303 |issue= 1 |pages= 69–72 |year= 1992 |pmid= 1592118 |doi=

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