HAX1

HCLS1 associated protein X-1, also known as HAX1, is a human gene.cite web | title = Entrez Gene: HAX1 HCLS1 associated protein X-1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10456| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is known to associate with HS1, a substrate of Src family tyrosine kinases. It also interacts with the product of PKD2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: HAX1 HCLS1 associated protein X-1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10456| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Modem S, Reddy TR |title=An anti-apoptotic protein, Hax-1, inhibits the HIV-1 rev function by altering its sub-cellular localization. |journal=J. Cell. Physiol. |volume=214 |issue= 1 |pages= 14–9 |year= 2007 |pmid= 17929250 |doi= 10.1002/jcp.21305
*cite journal | author=Klein C, Grudzien M, Appaswamy G, "et al." |title=HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease). |journal=Nat. Genet. |volume=39 |issue= 1 |pages= 86–92 |year= 2007 |pmid= 17187068 |doi= 10.1038/ng1940
*cite journal | author=Kawaguchi Y, Nishimagi E, Tochimoto A, "et al." |title=Intracellular IL-1alpha-binding proteins contribute to biological functions of endogenous IL-1alpha in systemic sclerosis fibroblasts. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 39 |pages= 14501–6 |year= 2006 |pmid= 16971486 |doi= 10.1073/pnas.0603545103
*cite journal | author=Han Y, Chen YS, Liu Z, "et al." |title=Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition. |journal=Circ. Res. |volume=99 |issue= 4 |pages= 415–23 |year= 2006 |pmid= 16857965 |doi= 10.1161/01.RES.0000237387.05259.a5
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ortiz DF, Moseley J, Calderon G, "et al." |title=Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells. |journal=J. Biol. Chem. |volume=279 |issue= 31 |pages= 32761–70 |year= 2004 |pmid= 15159385 |doi= 10.1074/jbc.M404337200
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Mirmohammadsadegh A, Tartler U, Michel G, "et al." |title=HAX-1, identified by differential display reverse transcription polymerase chain reaction, is overexpressed in lesional psoriasis. |journal=J. Invest. Dermatol. |volume=120 |issue= 6 |pages= 1045–51 |year= 2003 |pmid= 12787133 |doi= 10.1046/j.1523-1747.2003.12247.x
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yin H, Morioka H, Towle CA, "et al." |title=Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein. |journal=Cytokine |volume=15 |issue= 3 |pages= 122–37 |year= 2001 |pmid= 11554782 |doi= 10.1006/cyto.2001.0891
*cite journal | author=Gallagher AR, Cedzich A, Gretz N, "et al." |title=The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 4017–22 |year= 2000 |pmid= 10760273 |doi=
*cite journal | author=Suzuki Y, Demoliere C, Kitamura D, "et al." |title=HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases. |journal=J. Immunol. |volume=158 |issue= 6 |pages= 2736–44 |year= 1997 |pmid= 9058808 |doi=

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