Homotaurine

Chembox new
Reference= [ [http://www.sigmaaldrich.com/catalog/search/ProductDetail/ALDRICH/A76109 Homotaurine] at Sigma-Aldrich]
ImageFile=Homotaurine.pngImageSize=200px
IUPACName=3-Aminopropane-1-sulfonic acid
OtherNames=Tramiprosate
Alzhemed
Section1= Chembox Identifiers
CASNo=3687-18-1
PubChem=1646
SMILES=C(CN)CS(=O)(=O)O
Section2= Chembox Properties
Formula=C₃H₉NO₃S
MolarMass=139.17346
Appearance=
Density=
MeltingPt=293 °C (decomposition)
BoilingPt=
Solubility=
Section3= Chembox Hazards
MainHazards=
FlashPt=
Autoignition=
RPhrases=R36/37/38
SPhrases=S26 S36

Homotaurine (also spelled homotaurin) is a synthetic organic compound. It is analogous to taurine, but with an extra carbon in its chain. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. [cite journal |author=Fariello RG, Golden GT, Pisa M |title=Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid |journal=Neurology |volume=32 |issue=3 |pages=241–5 |year=1982 |pmid=7199633 |doi=]

Homotaurine is also being investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. [cite journal |author=Aisen PS, Gauthier S, Vellas B, "et al" |title=Alzhemed: a potential treatment for Alzheimer's disease |journal=Curr Alzheimer Res |volume=4 |issue=4 |pages=473–8 |year=2007 |pmid=17908052 |doi=]

Homotaurine is a zwitterion at neutral pH.

References