CDK2AP1

CDK2-associated protein 1, also known as CDK2AP1, is a human gene.cite web | title = Entrez Gene: CDK2AP1 CDK2-associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8099| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes.cite web | title = Entrez Gene: CDK2AP1 CDK2-associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8099| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Daigo Y, Suzuki K, Maruyama O, "et al." |title=Isolation, mapping and mutation analysis of a human cDNA homologous to the doc-1 gene of the Chinese hamster, a candidate tumor suppressor for oral cancer. |journal=Genes Chromosomes Cancer |volume=20 |issue= 2 |pages= 204–7 |year= 1997 |pmid= 9331572 |doi=
*cite journal | author=Tsuji T, Duh FM, Latif F, "et al." |title=Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1. |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6704–9 |year= 1998 |pmid= 9506968 |doi=
*cite journal | author=Matsuo K, Shintani S, Tsuji T, "et al." |title=p12(DOC-1), a growth suppressor, associates with DNA polymerase alpha/primase. |journal=FASEB J. |volume=14 |issue= 10 |pages= 1318–24 |year= 2000 |pmid= 10877824 |doi=
*cite journal | author=Shintani S, Ohyama H, Zhang X, "et al." |title=p12(DOC-1) is a novel cyclin-dependent kinase 2-associated protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 17 |pages= 6300–7 |year= 2000 |pmid= 10938106 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yuan Z, Sotsky Kent T, Weber TK |title=Differential expression of DOC-1 in microsatellite-unstable human colorectal cancer. |journal=Oncogene |volume=22 |issue= 40 |pages= 6304–10 |year= 2003 |pmid= 13679870 |doi= 10.1038/sj.onc.1206609
*cite journal | author=Hu MG, Hu GF, Kim Y, "et al." |title=Role of p12(CDK2-AP1) in transforming growth factor-beta1-mediated growth suppression. |journal=Cancer Res. |volume=64 |issue= 2 |pages= 490–9 |year= 2004 |pmid= 14744761 |doi=
*cite journal | author=Buajeeb W, Zhang X, Ohyama H, "et al." |title=Interaction of the CDK2-associated protein-1, p12(DOC-1/CDK2AP1), with its homolog, p14(DOC-1R). |journal=Biochem. Biophys. Res. Commun. |volume=315 |issue= 4 |pages= 998–1003 |year= 2004 |pmid= 14985111 |doi= 10.1016/j.bbrc.2004.02.003
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kim Y, Ohyama H, Patel V, "et al." |title=Mutation of Cys105 inhibits dimerization of p12CDK2-AP1 and its growth suppressor effect. |journal=J. Biol. Chem. |volume=280 |issue= 24 |pages= 23273–9 |year= 2005 |pmid= 15840587 |doi= 10.1074/jbc.M412929200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Peng H, Shintani S, Kim Y, Wong DT |title=Loss of p12CDK2-AP1 expression in human oral squamous cell carcinoma with disrupted transforming growth factor-beta-Smad signaling pathway. |journal=Neoplasia |volume=8 |issue= 12 |pages= 1028–36 |year= 2007 |pmid= 17217620 |doi= 10.1593/neo.06580
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Shin J, Yuan Z, Fordyce K, "et al." |title=A del T poly T (8) mutation in the 3' untranslated region (UTR) of the CDK2-AP1 gene is functionally significant causing decreased mRNA stability resulting in decreased CDK2-AP1 expression in human microsatellite unstable (MSI) colorectal cancer (CRC). |journal=Surgery |volume=142 |issue= 2 |pages= 222–7 |year= 2007 |pmid= 17689689 |doi= 10.1016/j.surg.2007.04.002

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