UVRAG

UV radiation resistance associated gene, also known as UVRAG, is a human gene.cite web | title = Entrez Gene: UVRAG UV radiation resistance associated gene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7405| accessdate = ]

PBB_Summary
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summary_text = This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.cite web | title = Entrez Gene: UVRAG UV radiation resistance associated gene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7405| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Liang C, Feng P, Ku B, "et al." |title=UVRAG: a new player in autophagy and tumor cell growth. |journal=Autophagy |volume=3 |issue= 1 |pages= 69–71 |year= 2007 |pmid= 17106237 |doi=
*cite journal | author=Teitz T, Penner M, Eli D, "et al." |title=Isolation by polymerase chain reaction of a cDNA whose product partially complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells. |journal=Gene |volume=87 |issue= 2 |pages= 295–8 |year= 1990 |pmid= 2332174 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Perelman B, Dafni N, Naiman T, "et al." |title=Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus. |journal=Genomics |volume=41 |issue= 3 |pages= 397–405 |year= 1997 |pmid= 9169138 |doi= 10.1006/geno.1997.4623
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Bekri S, Adélaïde J, Merscher S, "et al." |title=Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1-2 |pages= 125–31 |year= 1998 |pmid= 9533029 |doi=
*cite journal | author=Iida A, Emi M, Matsuoka R, "et al." |title=Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation. |journal=Hum. Genet. |volume=106 |issue= 3 |pages= 277–87 |year= 2000 |pmid= 10798355 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Goi T, Kawasaki M, Yamazaki T, "et al." |title=Ascending colon cancer with hepatic metastasis and cholecystolithiasis in a patient with situs inversus totalis without any expression of UVRAG mRNA: report of a case. |journal=Surg. Today |volume=33 |issue= 9 |pages= 702–6 |year= 2004 |pmid= 12928850 |doi= 10.1007/s00595-002-2567-y
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Ionov Y, Nowak N, Perucho M, "et al." |title=Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability. |journal=Oncogene |volume=23 |issue= 3 |pages= 639–45 |year= 2004 |pmid= 14737099 |doi= 10.1038/sj.onc.1207178
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Liang C, Feng P, Ku B, "et al." |title=Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. |journal=Nat. Cell Biol. |volume=8 |issue= 7 |pages= 688–99 |year= 2006 |pmid= 16799551 |doi= 10.1038/ncb1426

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