ZP4

Zona pellucida glycoprotein 4, also known as ZP4, is a human gene.cite web | title = Entrez Gene: ZP4 zona pellucida glycoprotein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57829| accessdate = ]

PBB_Summary
section_title =
summary_text = The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4.cite web | title = Entrez Gene: ZP4 zona pellucida glycoprotein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57829| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rankin T, Dean J |title=The zona pellucida: using molecular genetics to study the mammalian egg coat. |journal=Rev. Reprod. |volume=5 |issue= 2 |pages= 114–21 |year= 2000 |pmid= 10864856 |doi=
*cite journal | author=Harris JD, Hibler DW, Fontenot GK, "et al." |title=Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: the ZPA, ZPB and ZPC gene families. |journal=DNA Seq. |volume=4 |issue= 6 |pages= 361–93 |year= 1995 |pmid= 7841460 |doi=
*cite journal | author=Eberspaecher U, Becker A, Bringmann P, "et al." |title=Immunohistochemical localization of zona pellucida proteins ZPA, ZPB and ZPC in human, cynomolgus monkey and mouse ovaries. |journal=Cell Tissue Res. |volume=303 |issue= 2 |pages= 277–87 |year= 2001 |pmid= 11291774 |doi=
*cite journal | author=Kiefer SM, Saling P |title=Proteolytic processing of human zona pellucida proteins. |journal=Biol. Reprod. |volume=66 |issue= 2 |pages= 407–14 |year= 2002 |pmid= 11804956 |doi=
*cite journal | author=Qi H, Williams Z, Wassarman PM |title=Secretion and assembly of zona pellucida glycoproteins by growing mouse oocytes microinjected with epitope-tagged cDNAs for mZP2 and mZP3. |journal=Mol. Biol. Cell |volume=13 |issue= 2 |pages= 530–41 |year= 2002 |pmid= 11854410 |doi= 10.1091/mbc.01-09-0440
*cite journal | author=Zhao M, Gold L, Ginsberg AM, "et al." |title=Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice. |journal=Mol. Cell. Biol. |volume=22 |issue= 9 |pages= 3111–20 |year= 2002 |pmid= 11940668 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lefièvre L, Conner SJ, Salpekar A, "et al." |title=Four zona pellucida glycoproteins are expressed in the human. |journal=Hum. Reprod. |volume=19 |issue= 7 |pages= 1580–6 |year= 2005 |pmid= 15142998 |doi= 10.1093/humrep/deh301
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Chakravarty S, Suraj K, Gupta SK |title=Baculovirus-expressed recombinant human zona pellucida glycoprotein-B induces acrosomal exocytosis in capacitated spermatozoa in addition to zona pellucida glycoprotein-C. |journal=Mol. Hum. Reprod. |volume=11 |issue= 5 |pages= 365–72 |year= 2005 |pmid= 15805145 |doi= 10.1093/molehr/gah165
*cite journal | author=Furlong LI, Harris JD, Vazquez-Levin MH |title=Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. |journal=Fertil. Steril. |volume=83 |issue= 6 |pages= 1780–90 |year= 2006 |pmid= 15950651 |doi= 10.1016/j.fertnstert.2004.12.042
*cite journal | author=Caballero-Campo P, Chirinos M, Fan XJ, "et al." |title=Biological effects of recombinant human zona pellucida proteins on sperm function. |journal=Biol. Reprod. |volume=74 |issue= 4 |pages= 760–8 |year= 2006 |pmid= 16407501 |doi= 10.1095/biolreprod.105.047522
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727

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