LOXL1

LOXL1

Lysyl oxidase-like 1, also known as LOXL1, is a human gene.cite web | title = Entrez Gene: LOXL1 lysyl oxidase-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4016| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.cite web | title = Entrez Gene: LOXL1 lysyl oxidase-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4016| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Csiszar K |title=Lysyl oxidases: a novel multifunctional amine oxidase family. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=70 |issue= |pages= 1–32 |year= 2001 |pmid= 11642359 |doi=
*cite journal | author=Kagan HM, Li W |title=Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. |journal=J. Cell. Biochem. |volume=88 |issue= 4 |pages= 660–72 |year= 2003 |pmid= 12577300 |doi= 10.1002/jcb.10413
*cite journal | author=Molnar J, Fong KS, He QP, "et al." |title=Structural and functional diversity of lysyl oxidase and the LOX-like proteins. |journal=Biochim. Biophys. Acta |volume=1647 |issue= 1-2 |pages= 220–4 |year= 2003 |pmid= 12686136 |doi=
*cite journal | author=Kenyon K, Modi WS, Contente S, Friedman RM |title=A novel human cDNA with a predicted protein similar to lysyl oxidase maps to chromosome 15q24-q25. |journal=J. Biol. Chem. |volume=268 |issue= 25 |pages= 18435–7 |year= 1993 |pmid= 7689553 |doi=
*cite journal | author=Kim Y, Boyd CD, Csiszar K |title=A new gene with sequence and structural similarity to the gene encoding human lysyl oxidase. |journal=J. Biol. Chem. |volume=270 |issue= 13 |pages= 7176–82 |year= 1995 |pmid= 7706256 |doi=
*cite journal | author=Goy A, Gilles F, Remache Y, Zelenetz AD |title=Physical linkage of the lysyl oxidase-like (LOXL1) gene to the PML gene on human chromosome 15q22. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 1-2 |pages= 22–4 |year= 2000 |pmid= 10773658 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jung ST, Kim MS, Seo JY, "et al." |title=Purification of enzymatically active human lysyl oxidase and lysyl oxidase-like protein from Escherichia coli inclusion bodies. |journal=Protein Expr. Purif. |volume=31 |issue= 2 |pages= 240–6 |year= 2004 |pmid= 14550642 |doi=
*cite journal | author=Liu X, Zhao Y, Gao J, "et al." |title=Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. |journal=Nat. Genet. |volume=36 |issue= 2 |pages= 178–82 |year= 2004 |pmid= 14745449 |doi= 10.1038/ng1297
*cite journal | author=Noblesse E, Cenizo V, Bouez C, "et al." |title=Lysyl oxidase-like and lysyl oxidase are present in the dermis and epidermis of a skin equivalent and in human skin and are associated to elastic fibers. |journal=J. Invest. Dermatol. |volume=122 |issue= 3 |pages= 621–30 |year= 2004 |pmid= 15086544 |doi= 10.1111/j.0022-202X.2004.22330.x
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Thomassin L, Werneck CC, Broekelmann TJ, "et al." |title=The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers. |journal=J. Biol. Chem. |volume=280 |issue= 52 |pages= 42848–55 |year= 2006 |pmid= 16251195 |doi= 10.1074/jbc.M506832200
*cite journal | author=Cenizo V, André V, Reymermier C, "et al." |title=LOXL as a target to increase the elastin content in adult skin: a dill extract induces the LOXL gene expression. |journal=Exp. Dermatol. |volume=15 |issue= 8 |pages= 574–81 |year= 2007 |pmid= 16842595 |doi= 10.1111/j.1600-0625.2006.00442.x
*cite journal | author=Thorleifsson G, Magnusson KP, Sulem P, "et al." |title=Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma. |journal=Science |volume=317 |issue= 5843 |pages= 1397–400 |year= 2007 |pmid= 17690259 |doi= 10.1126/science.1146554
*cite journal | author=Damji KF |title=Progress in understanding pseudoexfoliation syndrome and pseudoexfoliation-associated glaucoma. |journal=Can. J. Ophthalmol. |volume=42 |issue= 5 |pages= 657–8 |year= 2007 |pmid= 17891191 |doi= 10.1139/i07-158

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