TAF5L

TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa, also known as TAF5L, is a human gene.cite web | title = Entrez Gene: TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27097| accessdate = ]

PBB_Summary
section_title =
summary_text = The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.cite web | title = Entrez Gene: TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27097| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Struhl K, Moqtaderi Z |title=The TAFs in the HAT. |journal=Cell |volume=94 |issue= 1 |pages= 1–4 |year= 1998 |pmid= 9674419 |doi=
*cite journal | author=Ogryzko VV, Kotani T, Zhang X, "et al." |title=Histone-like TAFs within the PCAF histone acetylase complex. |journal=Cell |volume=94 |issue= 1 |pages= 35–44 |year= 1998 |pmid= 9674425 |doi=
*cite journal | author=Brand M, Yamamoto K, Staub A, Tora L |title=Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18285–9 |year= 1999 |pmid= 10373431 |doi=
*cite journal | author=Stanchi F, Bertocco E, Toppo S, "et al." |title=Characterization of 16 novel human genes showing high similarity to yeast sequences. |journal=Yeast |volume=18 |issue= 1 |pages= 69–80 |year= 2001 |pmid= 11124703 |doi= 10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H |doilabel=10.1002/1097-0061(200101)18:169::AID-YEA6473.0.CO;2-H
*cite journal | author=Brand M, Moggs JG, Oulad-Abdelghani M, "et al." |title=UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. |journal=EMBO J. |volume=20 |issue= 12 |pages= 3187–96 |year= 2001 |pmid= 11406595 |doi= 10.1093/emboj/20.12.3187
*cite journal | author=Martinez E, Palhan VB, Tjernberg A, "et al." |title=Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6782–95 |year= 2001 |pmid= 11564863 |doi= 10.1128/MCB.21.20.6782-6795.2001
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Cavusoglu N, Brand M, Tora L, Van Dorsselaer A |title=Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis. |journal=Proteomics |volume=3 |issue= 2 |pages= 217–23 |year= 2003 |pmid= 12601814 |doi= 10.1002/pmic.200390030
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Zhang K, Faiola F, Martinez E |title=Six lysine residues on c-Myc are direct substrates for acetylation by p300. |journal=Biochem. Biophys. Res. Commun. |volume=336 |issue= 1 |pages= 274–80 |year= 2005 |pmid= 16126174 |doi= 10.1016/j.bbrc.2005.08.075
*cite journal | author=Chistiakov DA, Chernisheva A, Savost'anov KV, "et al." |title=The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients. |journal=Autoimmunity |volume=38 |issue= 4 |pages= 283–93 |year= 2005 |pmid= 16206511 |doi=
*cite journal | author=Kuninger D, Wright A, Rotwein P |title=Muscle cell survival mediated by the transcriptional coactivators p300 and PCAF displays different requirements for acetyltransferase activity. |journal=Am. J. Physiol., Cell Physiol. |volume=291 |issue= 4 |pages= C699–709 |year= 2006 |pmid= 16672693 |doi= 10.1152/ajpcell.00056.2006
*cite journal | author=Okumura K, Mendoza M, Bachoo RM, "et al." |title=PCAF modulates PTEN activity. |journal=J. Biol. Chem. |volume=281 |issue= 36 |pages= 26562–8 |year= 2006 |pmid= 16829519 |doi= 10.1074/jbc.M605391200
*cite journal | author=Ravnskjaer K, Kester H, Liu Y, "et al." |title=Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. |journal=EMBO J. |volume=26 |issue= 12 |pages= 2880–9 |year= 2007 |pmid= 17476304 |doi= 10.1038/sj.emboj.7601715

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