GEM (gene)

GTP binding protein overexpressed in skeletal muscle, also known as GEM, is a human gene.cite web | title = Entrez Gene: GEM GTP binding protein overexpressed in skeletal muscle| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2669| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.cite web | title = Entrez Gene: GEM GTP binding protein overexpressed in skeletal muscle| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2669| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Cohen L, Mohr R, Chen YY, "et al." |title=Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 26 |pages= 12448–52 |year= 1995 |pmid= 7809057 |doi=
*cite journal | author=Maguire J, Santoro T, Jensen P, "et al." |title=Gem: an induced, immediate early protein belonging to the Ras family. |journal=Science |volume=265 |issue= 5169 |pages= 241–4 |year= 1994 |pmid= 7912851 |doi=
*cite journal | author=Santoro T, Maguire J, McBride OW, "et al." |title=Chromosomal organization and transcriptional regulation of human GEM and localization of the human and mouse GEM loci encoding an inducible Ras-like protein. |journal=Genomics |volume=30 |issue= 3 |pages= 558–64 |year= 1997 |pmid= 8825643 |doi= 10.1006/geno.1995.1277
*cite journal | author=Moyers JS, Bilan PJ, Zhu J, Kahn CR |title=Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II. |journal=J. Biol. Chem. |volume=272 |issue= 18 |pages= 11832–9 |year= 1997 |pmid= 9115241 |doi=
*cite journal | author=Béguin P, Nagashima K, Gonoi T, "et al." |title=Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem. |journal=Nature |volume=411 |issue= 6838 |pages= 701–6 |year= 2001 |pmid= 11395774 |doi= 10.1038/35079621
*cite journal | author=Ward Y, Yap SF, Ravichandran V, "et al." |title=The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway. |journal=J. Cell Biol. |volume=157 |issue= 2 |pages= 291–302 |year= 2002 |pmid= 11956230 |doi= 10.1083/jcb.200111026
*cite journal | author=Aresta S, de Tand-Heim MF, Béranger F, de Gunzburg J |title=A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases. |journal=Biochem. J. |volume=367 |issue= Pt 1 |pages= 57–65 |year= 2003 |pmid= 12093360 |doi= 10.1042/BJ20020829
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kelly K |title=The RGK family: a regulatory tail of small GTP-binding proteins. |journal=Trends Cell Biol. |volume=15 |issue= 12 |pages= 640–3 |year= 2006 |pmid= 16242932 |doi= 10.1016/j.tcb.2005.10.002
*cite journal | author=Opatowsky Y, Sasson Y, Shaked I, "et al." |title=Structure-function studies of the G-domain from human gem, a novel small G-protein. |journal=FEBS Lett. |volume=580 |issue= 25 |pages= 5959–64 |year= 2006 |pmid= 17052716 |doi= 10.1016/j.febslet.2006.09.067
*cite journal | author=Splingard A, Ménétrey J, Perderiset M, "et al." |title=Biochemical and structural characterization of the gem GTPase. |journal=J. Biol. Chem. |volume=282 |issue= 3 |pages= 1905–15 |year= 2007 |pmid= 17107948 |doi= 10.1074/jbc.M604363200

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