VPS45

Vacuolar protein sorting 45 homolog (S. cerevisiae), also known as VPS45, is a human gene.cite web | title = Entrez Gene: VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11311| accessdate = ]

PBB_Summary
section_title =
summary_text = Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators.cite web | title = Entrez Gene: VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11311| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Pevsner J, Hsu SC, Hyde PS, Scheller RH |title=Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking. |journal=Gene |volume=183 |issue= 1-2 |pages= 7–14 |year= 1997 |pmid= 8996080 |doi=
*cite journal | author=Tellam JT, James DE, Stevens TH, Piper RC |title=Identification of a mammalian Golgi Sec1p-like protein, mVps45. |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6187–93 |year= 1997 |pmid= 9045632 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Rajasekariah P, Eyre HJ, Stanley KK, "et al." |title=Molecular cloning and characterization of a cDNA encoding the human leucocyte vacuolar protein sorting (h1Vps45). |journal=Int. J. Biochem. Cell Biol. |volume=31 |issue= 6 |pages= 683–94 |year= 1999 |pmid= 10404641 |doi=
*cite journal | author=Nielsen E, Christoforidis S, Uttenweiler-Joseph S, "et al." |title=Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. |journal=J. Cell Biol. |volume=151 |issue= 3 |pages= 601–12 |year= 2000 |pmid= 11062261 |doi=
*cite journal | author=de Renzis S, Sönnichsen B, Zerial M |title=Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes. |journal=Nat. Cell Biol. |volume=4 |issue= 2 |pages= 124–33 |year= 2002 |pmid= 11788822 |doi= 10.1038/ncb744
*cite journal | author=Dulubova I, Yamaguchi T, Gao Y, "et al." |title=How Tlg2p/syntaxin 16 'snares' Vps45. |journal=EMBO J. |volume=21 |issue= 14 |pages= 3620–31 |year= 2002 |pmid= 12110575 |doi= 10.1093/emboj/cdf381
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kim BY, Ueda M, Kominami E, "et al." |title=Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex. |journal=Biochem. Biophys. Res. Commun. |volume=311 |issue= 3 |pages= 577–82 |year= 2004 |pmid= 14623309 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406

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