AKAP3

A kinase (PRKA) anchor protein 3, also known as AKAP3, is a human gene.cite web | title = Entrez Gene: AKAP3 A kinase (PRKA) anchor protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10566| accessdate = ]

PBB_Summary
section_title =
summary_text = The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family, and is expressed in testis only. The encoded protein contains an RII-binding domain, and is predicted to participate in protein-protein interactions with the R-subunit of the PKA. This protein is localized to the ribs of the fibrous sheath in the principal piece of the sperm tail. It may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.cite web | title = Entrez Gene: AKAP3 A kinase (PRKA) anchor protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10566| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lester LB, Scott JD |title=Anchoring and scaffold proteins for kinases and phosphatases. |journal=Recent Prog. Horm. Res. |volume=52 |issue= |pages= 409–29; discussion 429–30 |year= 1997 |pmid= 9238861 |doi=
*cite journal | author=Michel JJ, Scott JD |title=AKAP mediated signal transduction. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=42 |issue= |pages= 235–57 |year= 2002 |pmid= 11807172 |doi= 10.1146/annurev.pharmtox.42.083101.135801
*cite journal | author=Vijayaraghavan S, Liberty GA, Mohan J, "et al." |title=Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein. |journal=Mol. Endocrinol. |volume=13 |issue= 5 |pages= 705–17 |year= 1999 |pmid= 10319321 |doi=
*cite journal | author=Lefevre A, Duquenne C, Rousseau-Merck MF, "et al." |title=Cloning and characterization of SOB1, a new testis-specific cDNA encoding a human sperm protein probably involved in oocyte recognition. |journal=Biochem. Biophys. Res. Commun. |volume=259 |issue= 1 |pages= 60–6 |year= 1999 |pmid= 10334916 |doi= 10.1006/bbrc.1999.0728
*cite journal | author=Mandal A, Naaby-Hansen S, Wolkowicz MJ, "et al." |title=FSP95, a testis-specific 95-kilodalton fibrous sheath antigen that undergoes tyrosine phosphorylation in capacitated human spermatozoa. |journal=Biol. Reprod. |volume=61 |issue= 5 |pages= 1184–97 |year= 1999 |pmid= 10529264 |doi=
*cite journal | author=Carr DW, Fujita A, Stentz CL, "et al." |title=Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17332–8 |year= 2001 |pmid= 11278869 |doi= 10.1074/jbc.M011252200
*cite journal | author=Niu J, Vaiskunaite R, Suzuki N, "et al." |title=Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation. |journal=Curr. Biol. |volume=11 |issue= 21 |pages= 1686–90 |year= 2002 |pmid= 11696326 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ficarro S, Chertihin O, Westbrook VA, "et al." |title=Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11579–89 |year= 2003 |pmid= 12509440 |doi= 10.1074/jbc.M202325200
*cite journal | author=Brown PR, Miki K, Harper DB, Eddy EM |title=A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum. |journal=Biol. Reprod. |volume=68 |issue= 6 |pages= 2241–8 |year= 2004 |pmid= 12606363 |doi= 10.1095/biolreprod.102.013466
*cite journal | author=Hasegawa K, Ono T, Matsushita H, "et al." |title=A-kinase anchoring protein 3 messenger RNA expression in ovarian cancer and its implication on prognosis. |journal=Int. J. Cancer |volume=108 |issue= 1 |pages= 86–90 |year= 2003 |pmid= 14618620 |doi= 10.1002/ijc.11565
*cite journal | author=Lea IA, Widgren EE, O'Rand MG |title=Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. |journal=Reprod. Biol. Endocrinol. |volume=2 |issue= |pages= 57 |year= 2004 |pmid= 15257753 |doi= 10.1186/1477-7827-2-57
*cite journal | author=Sharma S, Qian F, Keitz B, "et al." |title=A-kinase anchoring protein 3 messenger RNA expression correlates with poor prognosis in epithelial ovarian cancer. |journal=Gynecol. Oncol. |volume=99 |issue= 1 |pages= 183–8 |year= 2005 |pmid= 16005946 |doi= 10.1016/j.ygyno.2005.06.006
*cite journal | author=Lefièvre L, Chen Y, Conner SJ, "et al." |title=Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide? |journal=Proteomics |volume=7 |issue= 17 |pages= 3066–84 |year= 2007 |pmid= 17683036 |doi= 10.1002/pmic.200700254

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